In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Tachykinin receptors and tachykinin receptor antagonists

1993 • 649 citations

A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

1992 • 441 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.

1991 • 237 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

The non‐peptide tachykinin antagonist, CP‐96,345, is a potent inhibitor of neurogenic inflammation

1992 • 185 citations

Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts.

1984 • 173 citations

Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist

1992 • 171 citations

Species differences in affinities of non-peptide antagonists for substance p receptors

1991 • 163 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 160 citations

Characterization of the substance P receptor in rat brain cortex membranes and the inhibition of radioligand binding by guanine nucleotides.

1983 • 151 citations

Characterization of neurokinin receptors in various isolated organs by the use of selective agonists

1987 • 151 citations

Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P

1991 • 136 citations

Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance and related neurokinins

1986 • 132 citations

In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.

1991 • 129 citations

Possible existence of a new tachykinin receptor subtype in the guinea pig ileum

1992 • 126 citations

Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum

1991 • 119 citations

Demonstration of two distinct tachykinin receptors in rat brain cortex.

1985 • 100 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 88 citations

In vivo and in vitro pharmacology of SR 48,968, a non-peptide tachykinin NK2 receptor antagonist

1993 • 82 citations

Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig

1993 • 67 citations

A non‐peptide NK₁‐receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically

1993 • 67 citations

3H-neurokinin A labels a specific tachykinin-binding site in the rat duodenal smooth muscle.

1987 • 67 citations

Characterization of a Human NK₁ Tachykinin Receptor in the Astrocytoma Cell Line U 373 MG

1993 • 58 citations

Functional substance P receptors on a human astrocytoma cell line (U-373 MG)

1989 • 51 citations

Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK₁ antagonists

1993 • 51 citations

The Nonpeptide NK-2 Antagonist SR 48968 Is Also a NK-3 Antagonist in the Guinea Pig but Not in the Rat

1993 • 51 citations

Functional characterization of neurokinin‐1 receptors on human U373MG astrocytoma cells

1992 • 50 citations

Pharmacology of neurokinin receptors

1991 • 49 citations

Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors

1991 • 42 citations

Characterization of the Binding Sites of [3H]SR 48968, a Potent Nonpeptide Radioligand Antagonist of the Neurokinin-2 Receptor

1993 • 36 citations

The NK2 receptor antagonist SR48968 inhibits thalamic responses evoked by thermal but not mechanical nociception

1993 • 31 citations

Binding sites for [3H][Sar9, Met(O2)11]substance P in rat bain and guinea pig ileum

1991 • 27 citations

Substance P antagonists

1992 • 26 citations

Endothelium-dependent relaxant effect of neurokinins on rabbit aorta is mediated by the NK1 receptor

1992 • 24 citations

CP-96,345, a non-peptide antagonist of substance P. III. Cardiovascular effects in mammals unrelated to actions on substance P receptors

1992 • 20 citations

Substance p-evoked release of acetylcholine from isolated spinal cord of the newborn rat

1991 • 19 citations

CP-96,345, a non-peptide antagonist of substance P: II. Actions on substance P-induced hypotension and bronchoconstriction, and on depressor reflexes in mammals

1992 • 16 citations