Toll-like receptors in the pathogenesis of human disease

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

2000 • 2,023 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children

2002 • 1,810 citations

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

2008 • 1,268 citations

Toll-like Receptor 4 Polymorphisms and Atherogenesis

2002 • 1,030 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans

2001 • 865 citations

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

2001 • 806 citations

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

2003 • 789 citations

Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative Septic Shock

2002 • 732 citations

Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti

2000 • 714 citations

Antibodies to DNA

1998 • 672 citations

Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL

2001 • 659 citations

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

2004 • 624 citations

Severity of asthma is related to endotoxin in house dust.

1996 • 586 citations

A Novel Polymorphism in the Toll-Like Receptor 2 Gene and Its Potential Association with Staphylococcal Infection

2000 • 583 citations

Human Toll‐Like Receptor 4 Mutations but Not CD14 Polymorphisms Are Associated with an Increased Risk of Gram‐Negative Infections

2002 • 576 citations

Activation of Autoreactive B Cells by CpG dsDNA

2003 • 523 citations

The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

2004 • 427 citations

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

2004 • 416 citations

Chlamydial Heat Shock Protein 60 Activates Macrophages and Endothelial Cells Through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway

2002 • 416 citations

Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

2003 • 396 citations

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

2001 • 384 citations

A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

2003 • 362 citations

Dysregulation of LPS-Induced Toll-Like Receptor 4-MyD88 Complex Formation and IL-1 Receptor-Associated Kinase 1 Activation in Endotoxin-Tolerant Cells

2002 • 274 citations

Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

2003 • 267 citations

Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects

1989 • 266 citations

Toll-Like Receptor 4-Mediated Innate IL-10 Activates Antigen-Specific Regulatory T Cells and Confers Resistance toBordetella pertussisby Inhibiting Inflammatory Pathology

2003 • 263 citations

Cutting Edge: A Toll-Like Receptor 2 Polymorphism That Is Associated with Lepromatous Leprosy Is Unable to Mediate Mycobacterial Signaling

2003 • 261 citations

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients

2001 • 259 citations

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

2003 • 253 citations

Association of the Toll-Like Receptor 4 Gene Asp299Gly Polymorphism With Acute Coronary Events

2003 • 247 citations

Evidence for infectious agents in cardiovascular disease and atherosclerosis

2002 • 246 citations

Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients

2004 • 245 citations

House Dust Endotoxin and Allergic Sensitization in Children

2002 • 235 citations

Repetitive Elements in Mammalian Telomeres Suppress Bacterial DNA-Induced Immune Activation

2003 • 232 citations

Variants of Toll-Like Receptor 4 Modify the Efficacy of Statin Therapy and the Risk of Cardiovascular Events

2003 • 228 citations

A Functional Polymorphism of Toll‐like Receptor 4 Is Not Associated with Likelihood or Severity of Meningococcal Disease

2001 • 198 citations

Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients

2003 • 198 citations

Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations

2002 • 193 citations

Inherited disorders of NF-κB-mediated immunity in man

2003 • 185 citations

TLR4 gene variants modify endotoxin effects on asthma

2003 • 172 citations

Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations

2002 • 167 citations

Polymorphisms in Toll-Like Receptor 4 Are Not Associated with Asthma or Atopy-related Phenotypes

2002 • 167 citations

Sepsis Induces Apoptosis and Profound Depletion of Splenic Interdigitating and Follicular Dendritic Cells

2003 • 166 citations

Toll-like receptor 4 polymorphism and severity of atopy in asthmatics

2004 • 143 citations

Effects of functional Toll‐like receptor‐4 mutations on the immune response to human and experimental sepsis

2003 • 121 citations

Haemophilus influenzae Type b-Outer Membrane Protein Complex Glycoconjugate Vaccine Induces Cytokine Production by Engaging Human Toll-Like Receptor 2 (TLR2) and Requires the Presence of TLR2 for Optimal Immunogenicity

2004 • 121 citations

Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine.

1990 • 110 citations

Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome

2003 • 103 citations

Divergence of Bacterial Lipopolysaccharide Pro-apoptotic Signaling Downstream of IRAK-1

2002 • 67 citations

TIRAP mediates endotoxin-induced NF-κB activation and apoptosis in endothelial cells

2002 • 36 citations

Enhancing immunogenicity by CpG DNA.

2003 • 22 citations