Microvillar cell surface as a natural defense system against xenobiotics: a new interpretation of multidrug resistance

Arzneimittelforschung

2005 • 8,820 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1993 • 365 citations

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

1996 • 328 citations

Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells

1997 • 294 citations

Actin Filaments, Stereocilia, and Hair Cells: How Cells Count and Measure

1992 • 284 citations

Ca2+ Flow via Tunnels in Polarized Cells: Recharging of Apical Ca2+ Stores by Focal Ca2+ Entry through Basal Membrane Patch

1997 • 274 citations

Membrane Transport: Its Relation to Cellular Metabolic Rates

1975 • 255 citations

Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study.

1988 • 246 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 • 222 citations

Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.

1995 • 221 citations

Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.

1995 • 217 citations

Cell Cycle Regulation of Membrane Phospholipid Metabolism

1996 • 215 citations

Localization of the type 3 inositol 1,4,5-trisphosphate receptor in the Ca2+ wave trigger zone of pancreatic acinar cells.

1994 • 205 citations

Potentiation of Anticancer-Drug Cytotoxicity by Multidrug-Resistance Chemosensitizers Involves Alterationsin Membrane Fluidity Leading to Increased Membrane Permeability

1995 • 170 citations

Glucocorticoid-modulated gene expression of tissue- and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2.

1988 • 168 citations

The role of mdr2 P‐glycoprotein in hepatobiliary lipid transport

1997 • 167 citations

Hepatocellular ATP-binding Cassette Protein Expression Enhances ATP Release and Autocrine Regulation of Cell Volume

1997 • 165 citations

Syndecan expression regulates cell morphology and growth of mouse mammary epithelial tumor cells.

1992 • 165 citations

Villin induces microvilli growth and actin redistribution in transfected fibroblasts

1989 • 163 citations

Cytochromes P-450 in human hepatocyte plasma membrane: Recognition by several autoantibodies

1993 • 152 citations

Detection of Ca2+ entry through mechanosensitive channels localizes the site of mechanoelectrical transduction in hair cells.

1995 • 144 citations

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

1996 • 143 citations

Potentiation of Anticancer-Drug Cytotoxicity by Multidrug-Resistance Chemosensitizers Involves Alterationsin Membrane Fluidity Leading to Increased Membrane Permeability

1995 • 137 citations

A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.

1994 • 135 citations

Alternative Exon Splicing Controls a Translational Switch from Activator to Repressor Isoforms of Transcription Factor CREB during Spermatogenesis

1996 • 122 citations

Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels.

1996 • 118 citations

Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane.

1996 • 117 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts.

1992 • 109 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein

1996 • 104 citations

Hypotonically induced changes in the plasma membrane of cultured mammalian cells

1993 • 103 citations

CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance

1996 • 99 citations

Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells

1997 • 99 citations

Adenosine nucleotides in bile

1996 • 94 citations

Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line.

1989 • 91 citations

Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1996 • 87 citations

Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes

1997 • 77 citations

Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids

1998 • 76 citations

Differential expression of P‐glycoprotein genes in primary rat hepatocyte culture

1993 • 75 citations

Glucocorticoid and Cyclic Nucleotide Regulation of Plasminogen Activator and Plasminogen Activator-Inhibitor Gene Expression in Primary Cultures of Rat Hepatocytes

1989 • 72 citations

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.

1993 • 71 citations

Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability

1996 • 69 citations

Microvillar Ca++ signaling: A new view of an old problem

1999 • 69 citations

Region-specific Activity of the Plasma Membrane Ca2+Pump and Delayed Activation of Ca2+Entry Characterize the Polarized, Agonist-evoked Ca2+Signals in Exocrine Cells

1995 • 67 citations

Disintegration of cytoskeletal structure of actin filaments in energy-depleted endothelial cells

1993 • 66 citations

Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line caco-2.

2000 • 61 citations

Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the ?optical probe technique?

1998 • 57 citations

Is the multidrug resistance an ATP channel? Abraham EH, Prat AG, Gerweck L, Seneveratne T, Arceci RJ, Kramer R, Guidotti G, Cantiello HF. The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci USA 1993;90: 312–316

1993 • 54 citations

Calcium storage and release properties of F‐actin: evidence for the involvement of F‐actin in cellular calcium signaling

1996 • 52 citations

Inhibition of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (SERCA) by Polycyclic Aromatic Hydrocarbons in HPB-All Human T Cells and Other Tissues

1995 • 52 citations

Regulation of cell volume via microvillar ion channels

2000 • 46 citations

Differential modulation of P-glycoprotein expression by dexamethasone and 3-methycholanthrene in rat hepatocyte primary cultures

1994 • 42 citations

Hepatic cellular distribution of cytochrome P-450 IA1 in rainbow trout (Oncorhynchus mykiss): an immunohisto- and cytochemical study.

1993 • 41 citations

Stable differentiation of a human colon adenocarcinoma cell line by sodium butyrate is associated with multidrug resistance

1994 • 41 citations

Microvillar Ion Channels: Cytoskeletal Modulation of Ion Fluxes

2000 • 40 citations

Ganglioside GM1 prevents and reverses toluene-induced increases in membrane fluidity and calcium levels in rat brain synaptosomes

1990 • 40 citations

Glucose absorption and utilization by rat embryos.

1997 • 40 citations

Protective role for proteoglycans against cationic lipid cytotoxicity allowing optimal transfection efficiency in vitro

1999 • 38 citations

Modulation of hepatic content and biliary excretion of P-glycoproteins in hepatocellular and obstructive cholestasis in the rat

1996 • 37 citations

Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.

1995 • 36 citations

Expression of Drosophila melanogaster P-glycoproteins is associated with ATP channel activity

1996 • 35 citations

Capacitative Ca2+ entry (CCE) induced by luminal and basolateral ATP in polarised MDCK-C7 cells is restricted to the basolateral membrane

1997 • 35 citations

Increasing aromatase cytochrome P-450 level in human placenta during pregnancy: studied by immunohistochemistry and enzyme-linked immunosorbent assay.

1992 • 35 citations

Plasma membranes from intestinal microvilli and erythrocytes contain cytochromes b5 and P-420

1980 • 34 citations

Actin conformation is drastically altered by direct interaction with membrane lipids: A differential scanning calorimetry study

1993 • 34 citations

Halothane and octanol block Ca2+ oscillations in pancreatic acini by multiple mechanisms

1995 • 33 citations

Immunoelectron microscopic localization of aromatase in human placenta and ovary using microwave fixation.

1990 • 30 citations

Insulin‐responsive glucose transporters are concentrated in a cell surfacederived membrane fraction of 3T3‐L1 adipocytes

1990 • 30 citations

Heat-shock-stimulated transepithelial daunomycin secretion by flounder renal proximal tubule primary cultures

1995 • 30 citations

The IP3‐sensitive calcium store of HIT cells is located in a surface‐derived vesicle fraction

1993 • 29 citations

Perturbation of artificial and biological membranes by organic compounds of aliphatic, alicyclic and aromatic structure

1996 • 28 citations

Verapamil competes with doxorubicin for binding to anionic phospholipids resulting in increased internal concentrations and rates of passive transport of doxorubicin

1995 • 28 citations

Action of Insulin on the Surface Morphology of Hepatocytes: Role of Phosphatidylinositol 3-kinase in Insulin-Induced Shape Change of Microvilli

1998 • 27 citations

Constitutive expression of functional P‐glycoprotein in rat hepatoma cells

1994 • 26 citations

Research on the mechanism of interaction between actin and membrane lipids

1990 • 26 citations

Evidence for location of the CFTR in human placental apical membrane vesicles

1995 • 25 citations

Evidence of direct interaction between actin and membrane lipids

1989 • 25 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Elevates Basal B-Cell Intracellular Calcium Concentration and Suppresses Surface Ig- but Not CD40-Induced Antibody Secretion

1996 • 25 citations

Double effect of ethanol on intracellular Ca2+ levels in undifferentiated PC12 cells

1995 • 25 citations

Circumvention of confluence‐dependent resistance in a human multi‐drug‐resistant colon‐cancer cell line

1995 • 25 citations

Activation of Calcium Signaling in Isolated Rat Hepatocytes Is Accompanied by Shape Changes of Microvilli

1997 • 25 citations

Hormone-regulated Ca2+ channel in rat hepatocytes revealed by whole cell patch clamp

1995 • 24 citations

Fluidity of the microsomal membrane and cytochrome P450 reduction kinetics of pig liver microsomes as a consequence of organic solvent impact

1993 • 24 citations

Expression of intestinal alkaline phosphatase in human organs

1992 • 23 citations

Ethanol has different effects on Ca2+-transport ATPases of muscle, brain and blood platelets

1995 • 22 citations

Endogenous regulation of 2‐deoxyglucose uptake in c6 glioma cells correlates with cytoskeleton‐mediated changes of surface morphology

1989 • 21 citations

Ca2+-Dependent Activation of Phospholipases C and D from Mouse Peritoneal Macrophages by a Selective Trigger of Ca2+ Influx, γ-Hexachlorocyclohexane

1994 • 21 citations

Detection of aromatase cytochrome P450, 17α-hydroxylase cytochrome P450 and NADPH:P450 reductase on the surface of cells in which they are expressed

1996 • 21 citations

Overexpression of P-glycoprotein in heat-and/or drug-resistant hepatoma variants

1996 • 21 citations

Another Link between Phospholipid Transmembrane Migration and ABC Transporter Gene Family, Inferred from a Rare Inherited Disorder of Phosphatidylserine Externalization

1997 • 20 citations

Cell surface characteristics of proadipocytes growth arrested at the predifferentiation GD state. Defects associated with neoplastic transformation.

1983 • 20 citations

Urokinase binds to a plasminogen activator inhibitor type-2-like molecule in placental microvillous membranes

1989 • 19 citations

Relationship between insulin stimulation and endogenous regulation of 2‐deoxyglucose uptake in 3T3‐L1 adipocytes

1990 • 19 citations

Sequential preparation of highly purified microvillous and basal syncytiotrophoblast membranes in substantial yield from a single term human placenta: inhibition of microvillous alkaline phosphatase activity by EDTA

1994 • 19 citations

Combined activity of interleukin-1 alpha or TNF-alpha and doxorubicin on multidrug resistant cell lines: evidence that TNF and DXR have synergistic antitumor and differentiation-inducing effects.

1994 • 19 citations

Polarized Ca2+ release in saponin-permeabilized parotid acinar cells evoked by flash photolysis of ‘caged’ inositol 1,4,5-trisphosphate

1998 • 19 citations

Rapid uptake of calcium, ATP, and inositol 1,4,5‐trisphosphate via cation and anion channels into surface‐derived vesicles from HIT cells containing the inositol 1,4,5‐trisphosphate‐sensitive calcium store

1993 • 18 citations

Association of canalicular membrane enzymes with bile acid micelles and lipid aggregates in human and rat bile

1995 • 18 citations

Restricted localization of the adipocyte/muscle glucose transporter species to a cell surface‐derived vesicle fraction of 3T3‐L1 adipocytes

1990 • 18 citations

The Chlorinated Insecticide 1,1-Dichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDD) Increases Intracellular Calcium in Rat Myometrial Smooth Muscle Cells

1995 • 17 citations

Occurrence of a reduced nicotinamide adenine dinucleotide oxidase activity linked to a cytochrome system in renal brush border membranes

1980 • 17 citations

Glucose causes lengthening of the microvilli of the neural plate of the rat embryo and produces a helical pattern on their surface

1993 • 16 citations

The involvement of cytoskeletal proteins in the maintenance of phospholipid topology in renal brush-border membranes

1988 • 16 citations

Detection of the ATP-Dependent Nonmitochondrial Calcium Store in a Cell Surface-Derived Vesicle Fraction from Isolated Rat Hepatocytes

1996 • 15 citations

Expression of multidrug resistance in response to differentiation in the K562 human leukaemia cell line

1995 • 14 citations

Exogenous ATP causes the contraction of intact fibroblasts in vitro

1988 • 14 citations

Inositol-1,4,5-Trisphosphate

1995 • 13 citations

The delta isomer of hexachlorocyclohexane induces rapid release of the myo-inositol-1,4,5-trisphosphate-sensitive Ca2+ store and blocks capacitative Ca2+ entry in rat basophilic leukemia cells.

1995 • 13 citations

ATP, Thapsigargin and cAMP Increase Ca2+ in Rat Hepatocytes by Activating Three Different Ca2+ Influx Pathways.

1997 • 13 citations

A histopathological study of anoxic-resuscitated liver allografts.

1997 • 13 citations

Cytochromes in the rat kidney brush border membrane

1978 • 11 citations

Biochemical and Morphological Characterization of Microvilli Isolated from Intestinal Mucosal Cells

1968 • 11 citations

A new concept for risk assessment of the hazards of non-genotoxic chemicals — electronmicroscopic studies of the cell surface. Evidence for the action of lipophilic chemicals on the Ca2+ signaling system

1997 • 10 citations

Modulation of MDR‐1 expression by a H‐ras oncogene in a human colon carcinoma cell line

1993 • 8 citations

Neural plate microvillus lengthening in rat embryos grown in various concentrations of glucose and further studies of the mechanism

1994 • 8 citations

Increase of alkaline phosphatase in multidrug-resistant tumor cells and their cross-resistance to 6-thioguanine.

1993 • 7 citations

2,2,4-Trimethylpentane induces Ca2+ release from the sarcoplasmic reticulum terminal cisterns

1991 • 5 citations

Drug-mucus actions and interactions.

1989 • 4 citations

Digital imaging of intracellular Ca2+ signaling in rat parotid acinar cells

1998 • 3 citations

Relation of the Activities of Plasminogen Activator and Plasmin-like Protease with Malignant Behavior of Skin Tumor of Rats

1988 • 1 citations

[The differentiation of tumor cells of the human large intestine during the acquisition of multiple drug resistance].

1993 • 1 citations