Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Liposomes : a practical approach

1990 • 1,092 citations

Handbook of Lipid Bilayers

2013 • 789 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil

1987 • 558 citations

Handbook of Lipid Bilayers, Second Edition

1990 • 527 citations

Effect of small molecules on the dipalmitoyl lecithin liposomal bilayer: III. Phase transition in lipid bilayer

1977 • 490 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

NMR in Molecular Biology

1981 • 336 citations

Evidence of a specific complex between adriamycin and negatively-charged phospholipids

1980 • 307 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Multidrug Resistance

1991 • 207 citations

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.

1993 • 166 citations

The Structure of Biological Membranes

1972 • 137 citations

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

1993 • 125 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.

1992 • 118 citations

Transmembrane Aromatic Amino Acid Distribution in P-glycoprotein

1994 • 116 citations

Reversal of multidrug resistance by phenothiazines and structurally related compounds

1992 • 114 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

Photoaffinity substrates for P-glycoprotein

1992 • 105 citations

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

1990 • 98 citations

Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells.

1987 • 97 citations

Differential modulation of P-glycoprotein transport by protein kinase inhibition

1993 • 93 citations

Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties

1993 • 88 citations

Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance

1994 • 86 citations

Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cells

1984 • 86 citations

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

1994 • 82 citations

Verapamil decreases P‐glycoprotein expression in multidrug‐resistant human leukemic cell lines

1994 • 81 citations

Resistance to Antineoplastic Drugs

1990 • 81 citations

Structural characteristics of compounds that modulate P-glycoprotein-associated multidrug resistance

1990 • 78 citations

Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.

1991 • 69 citations

Possible molecular basis for the pharmacokinetics and pharmacodynamics of three membrane-active drugs: Propranolol, nimodipine and amiodarone+

1988 • 53 citations

Role of anionic phospholipids in the interaction of doxorubicin and plasma membrane vesicles: Drug binding and structural consequences in bacterial systems

1993 • 52 citations

The Importance of Drug‐Membrane Interaction in Drug Research and Development

1992 • 43 citations

Reversal of multidrug resistance by a new lipophilic cationic molecule, S9788. Comparison with 11 other MDR-modulating agents in a model of doxorubicin-resistant rat glioblastoma cells

1993 • 33 citations

Structure-activity relationships of phenothiazines and related drugs for inhibition of protein kinase C.

1991 • 31 citations

Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice.

1991 • 30 citations

Cytoplasmic membrane cholesterol and doxorubicin cytotoxicity in drug-sensitive and multidrug-resistant human ovarian cancer cells.

1993 • 28 citations

N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells

1994 • 27 citations

Nuclear magnetic resonance and differential scanning calorimetry as tools for studying drug-membrane interactions

1991 • 22 citations

The relationship of doxorubicin binding to membrane lipids with drug resistance

1992 • 19 citations

Drug Accumulation and Binding in P-Glycoprotein-Associated Multidrug Resistance

1991 • 14 citations

Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells

1991 • 13 citations

Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to membrane enrichment and to 45Ca displacement from phosphatidylserine monolayers.

1990 • 13 citations

Membrane Lipids of Multidrug-Resistant Cells: Chemical Composition and Physical State

1991 • 9 citations

Analysis, in living cells, of the P-glycoprotein associated efflux of anthracyclines and of its inhibition by different classes of molecules

1994 • 1 citations

Competition between verapamil and doxorubicin for binding to anionic phospholipids

1994 • 1 citations

Characterization of altered intracellular drug distribution in LZ cells and primary human breast tumors

1994 • 1 citations

Inhibition of rhodamine-123 efflux and modulation of rhodamine-123 accumulation in CCRF VCR-1000 cells by dexniguldipine-HCl and other chemosensitizers

1994 • 1 citations

Lipids

1993 • 1 citations