Action of Insulin on the Surface Morphology of Hepatocytes: Role of Phosphatidylinositol 3-kinase in Insulin-Induced Shape Change of Microvilli

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

From signal to pseudopod

1989 • 460 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin.

1987 • 256 citations

Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes

1996 • 239 citations

Swelling of rat hepatocytes stimulates glycogen synthesis.

1990 • 201 citations

Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells

1994 • 196 citations

Localization of the Pancreatic Beta Cell Glucose Transporter to Specific Plasma Membrane Domains

1989 • 195 citations

Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

1996 • 194 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Massive Actin Polymerization Induced by Phosphatidylinositol-4-phosphate 5-Kinase in Vivo

1997 • 174 citations

Calcium and polyphosphoinositide control of cytoskeletal dynamics

1989 • 168 citations

Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes

1996 • 158 citations

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells.

1995 • 146 citations

Lipid Products of Phosphoinositide 3-Kinase Bind Human Profilin with High Affinity

1996 • 140 citations

Polarized distribution of glucose transporter isoforms in Caco-2 cells.

1992 • 124 citations

Glycolytic enzymes and a GLUT-1 glucose transporter in the outer segments of rod and cone photoreceptor cells.

1991 • 98 citations

Reduced beta-cell glucose transporter in new onset diabetic BB rats.

1990 • 90 citations

Regulation of glycogen synthesis and glycolysis by insulin, pH and cell volume. Interactions between swelling and alkalinization in mediating the effects of insulin

1992 • 73 citations

Novel functions of phosphatidylinositol 3-kinase in terminally differentiated cells

1995 • 72 citations

The role of cell swelling in the stimulation of glycogen synthesis by insulin

1992 • 60 citations

Role of Ca2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts

1991 • 55 citations

Calcium storage and release properties of F‐actin: evidence for the involvement of F‐actin in cellular calcium signaling

1996 • 52 citations

Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.

1996 • 48 citations

The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA synthesis

1995 • 40 citations

Insulin‐responsive glucose transporters are concentrated in a cell surfacederived membrane fraction of 3T3‐L1 adipocytes

1990 • 30 citations

The IP3‐sensitive calcium store of HIT cells is located in a surface‐derived vesicle fraction

1993 • 29 citations

Dissection of stress-activated glucose transport from insulin-induced glucose transport in mammalian cells using wortmannin and ML-9

1995 • 27 citations

Thrombin stimulates wortmannin-inhibitable phosphoinositide 3-kinase and membrane blebbing in CHRF-288 cells

1996 • 26 citations

Activation of Calcium Signaling in Isolated Rat Hepatocytes Is Accompanied by Shape Changes of Microvilli

1997 • 25 citations

Vasopressin-stimulated Electrogenic Sodium Transport in A6 Cells Is Linked to a Ca2+-mobilizing Signal Mechanism

1995 • 23 citations

Functional localization of glucose transporter 2 in rat liver.

1996 • 21 citations

Endogenous regulation of 2‐deoxyglucose uptake in c6 glioma cells correlates with cytoskeleton‐mediated changes of surface morphology

1989 • 21 citations

Growth Hormone Stimulation of Glucose Transport in Isolated Rat Hepatocyte Suspensions and Primary Cultures*

1981 • 21 citations

Expression and Localization of Glucose Transporter 1 (GLUT1) in the Rat Oviduct: A Possible Supplier of Glucose to Embryo During Early Embryonic Development

1995 • 20 citations

Relationship between insulin stimulation and endogenous regulation of 2‐deoxyglucose uptake in 3T3‐L1 adipocytes

1990 • 19 citations

Restricted localization of the adipocyte/muscle glucose transporter species to a cell surface‐derived vesicle fraction of 3T3‐L1 adipocytes

1990 • 18 citations

Rapid uptake of calcium, ATP, and inositol 1,4,5‐trisphosphate via cation and anion channels into surface‐derived vesicles from HIT cells containing the inositol 1,4,5‐trisphosphate‐sensitive calcium store

1993 • 18 citations

Glucose causes lengthening of the microvilli of the neural plate of the rat embryo and produces a helical pattern on their surface

1993 • 16 citations

Detection of the ATP-Dependent Nonmitochondrial Calcium Store in a Cell Surface-Derived Vesicle Fraction from Isolated Rat Hepatocytes

1996 • 15 citations

Effect of hormones on cytosolic free calcium in adipocytes

1989 • 14 citations

Insulin and ATP stimulate actin polymerization in U937 cells by a wortmannin‐sensitive mechanism

1996 • 11 citations

A new concept for risk assessment of the hazards of non-genotoxic chemicals — electronmicroscopic studies of the cell surface. Evidence for the action of lipophilic chemicals on the Ca2+ signaling system

1997 • 10 citations

Insulin stimulation of intracellular free Ca2+ recovery and Ca2+-ATPase gene expression in cultured vascular smooth-muscle cells: role of glucose 6-phosphate

1995 • 9 citations

3-O-methyl-D-glucose uptake in isolated rat hepatocytes. Effects of dexamethasone.

1983 • 6 citations

Attenuation of Insulin Actions in Primary Rat Hepatocyte Cultures by Phenylarsine Oxide

1993 • 4 citations