Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

1992 • 395 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

B7, a B-cell-restricted antigen that identifies preactivated B cells.

1987 • 211 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.

1995 • 149 citations

Evidence that CD4⁺, but not CD8⁺ T cells are responsible for murine interleukin‐2‐deficient colitis

1995 • 144 citations

Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

1992 • 139 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

CTLA4Ig TREATMENT AMELIORATES THE LETHALITY OF MURINE GRAFT-VERSUS-HOST DISEASE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS

1994 • 123 citations

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

1992 • 83 citations

sgp-60, a signal-transducing glycoprotein concerned with T cell activation through the T cell receptor/CD3 complex.

1990 • 35 citations