Identification and Expression of δ-Isoforms of the Multifunctional Ca ²⁺ /Calmodulin-Dependent Protein Kinase in Failing and Nonfailing Human Myocardium

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function

1995 • 812 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

1993 • 473 citations

Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.

1986 • 435 citations

Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs

1989 • 397 citations

Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.

1994 • 373 citations

Abnormal Intracellular Modulation of Calcium as a Major Cause of Cardiac Contractile Dysfunction

1991 • 309 citations

Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.

1994 • 251 citations

Molecular Basis of Human Cardiac Troponin T Isoforms Expressed in the Developing, Adult, and Failing Heart

1995 • 236 citations

Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene.

1992 • 231 citations

Structural features of Ca2+/calmodulin-dependent protein kinase II revealed by electron microscopy.

1991 • 227 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

1994 • 215 citations

The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes

1997 • 208 citations

Identification and characterization of δB-CaM kinase and δC-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms

1994 • 178 citations

Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain

1995 • 164 citations

Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta

1993 • 147 citations

lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

1994 • 115 citations

Sarcoplasmic reticulum calcium pump in cardiac and slow twitch skeletal muscle but not fast twitch skeletal muscle undergoes phosphorylation by endogenous and exogenous Ca2+/calmodulin-dependent protein kinase. Characterization of optimal conditions for calcium pump phosphorylation.

1994 • 114 citations

Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.

1992 • 108 citations

Phosphorylation at the Nuclear Localization Signal of Ca2+/Calmodulin-dependent Protein Kinase II Blocks Its Nuclear Targeting

1998 • 105 citations

Altered contractile function in heart failure

1998 • 105 citations

Phosphorylation of the purified cardiac ryanodine receptor by exogenous and endogenous protein kinases

1993 • 79 citations

Novel Ca2+/Calmodulin-dependent Protein Kinase II γ-Subunit Variants Expressed in Vascular Smooth Muscle, Brain, and Cardiomyocytes

1997 • 70 citations

Identification of novel human tumor cell-specific CaMK-II variants

1997 • 70 citations

Ventricular atrial natriuretic factor in the cardiomyopathic hamster model of congestive heart failure.

1988 • 63 citations

Voltage-Insensitive Ca²⁺ Channels and Ca²⁺/Calmodulin-Dependent Protein Kinases Propagate Signals from Endothelin-1 Receptors to the c-fos Promoter

1996 • 59 citations

The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct δ‐CaM kinase isozyme

1995 • 58 citations

Guanidinium Methods for Total RNA Preparation

1991 • 55 citations

Novel and uncommon isoforms of the calcium sensing enzyme calcium/calmodulin dependent protein kinase II in heart tissue

1995 • 54 citations

Differentiation-dependent expression of cardiac δ-CaMKII isoforms

1998 • 51 citations

Calcium sequestration by the sarcoplasmic reticulum in heart failure

1998 • 49 citations

Light‐Induced CREB Phosphorylation and Gene Expression in Rat Retinal Cells

1995 • 43 citations

Overexpression of Ca²⁺/Calmodulin-Dependent Protein Kinase II in PC12 Cells Alters Cell Growth, Morphology, and Nerve Growth Factor-Induced Differentiation

1997 • 38 citations

Light-Microscopic Evaluation of Myocardial Biopsies

1978 • 31 citations

Ca²⁺/Calmodulin‐Dependent Transcriptional Activation of Neuropeptide Y Gene Induced by Membrane Depolarization: Determination of Ca²⁺‐ and Cyclic AMP/Phorbol 12‐Myristate 13‐Acetate‐Responsive Elements

1996 • 22 citations

Immunopathogenesis of dilated cardiomyopathies

1995 • 19 citations