Regulated exocytosis and SNARE function (Review)

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

2000 • 1,397 citations

The release of neural transmitter substances

1969 • 1,134 citations

SNARE-mediated membrane fusion

2001 • 1,121 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release

1998 • 1,021 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Synaptotagmin I functions as a calcium regulator of release probability

2001 • 964 citations

The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.

1996 • 839 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

2000 • 783 citations

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

1999 • 759 citations

A conformational switch in syntaxin during exocytosis: role of munc18

1999 • 742 citations

A genomic perspective on membrane compartment organization

2001 • 693 citations

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

2000 • 692 citations

The release of neural transmitter substances

1970 • 685 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1997 • 673 citations

The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis

1999 • 623 citations

Calcium- and activity-dependent synaptic plasticity

1999 • 618 citations

UNC-13 is required for synaptic vesicle fusion in C. elegans

1999 • 601 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Snares and munc18 in synaptic vesicle fusion

2002 • 537 citations

Rab GTPases: specifying and deciphering organelle identity and function

2001 • 525 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

2001 • 513 citations

Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal

2000 • 511 citations

Morphological correlates of functionally defined synaptic vesicle populations

2001 • 505 citations

Mechanisms of Synaptic Vesicle Exocytosis

2000 • 502 citations

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

2001 • 501 citations

Synaptotagmins: Why So Many?

2002 • 497 citations

Complexins: Cytosolic proteins that regulate SNAP receptor function

1995 • 494 citations

A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion

2000 • 469 citations

Vesicle tethering complexes in membrane traffic

2002 • 456 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Three-Dimensional Structure of the Complexin/SNARE Complex

2002 • 449 citations

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

2001 • 435 citations

Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release

1998 • 422 citations

New Component of the Vacuolar Class C-Vps Complex Couples Nucleotide Exchange on the Ypt7 Gtpase to Snare-Dependent Docking and Fusion

2000 • 417 citations

Coiled Coils in Both Intracellular Vesicle and Viral Membrane Fusion

1998 • 412 citations

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

1995 • 404 citations

Real-time measurement of transmitter release from single synaptic vesicles

1995 • 404 citations

Neurotransmitter release — four years of SNARE complexes

1997 • 400 citations

Munc18-1 Promotes Large Dense-Core Vesicle Docking

2001 • 392 citations

Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain

2001 • 389 citations

Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

2000 • 373 citations

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes

2001 • 362 citations

THE JOURNAL of BIOLOGICAL CHEMISTRY

2009 • 354 citations

Differential Control of Vesicle Priming and Short-Term Plasticity by Munc13 Isoforms

2002 • 351 citations

Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A

1998 • 350 citations

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion

1999 • 327 citations

Drosophila Unc-13 is essential for synaptic transmission

1999 • 326 citations

The C2B Ca2+-binding motif of synaptotagmin is required for synaptic transmission in vivo

2002 • 322 citations

Spatial regulation of the exocyst complex by Rho1 GTPase

2001 • 321 citations

Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of Exocytosis

1999 • 319 citations

Cdc42 Interacts with the Exocyst and Regulates Polarized Secretion

2001 • 309 citations

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin

1997 • 306 citations

A Novel RING Finger Protein Complex Essential for a Late Step in Protein Transport to the Yeast Vacuole

1997 • 304 citations

THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION

1997 • 297 citations

Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles

2001 • 294 citations

Close Is Not Enough

2000 • 294 citations

Ypt and Rab GTPases: insight into functions through novel interactions

2001 • 291 citations

Topological restriction of SNARE-dependent membrane fusion

2000 • 288 citations

Vps52p, Vps53p, and Vps54p Form a Novel Multisubunit Complex Required for Protein Sorting at the Yeast Late Golgi

2000 • 288 citations

A Role for Giantin in Docking COPI Vesicles to Golgi Membranes

1998 • 284 citations

Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes

1999 • 277 citations

Identification of a Minimal Core of the Synaptic SNARE Complex Sufficient for Reversible Assembly and Disassembly

1998 • 276 citations

Class C Vps Protein Complex Regulates Vacuolar SNARE Pairing and Is Required for Vesicle Docking/Fusion

2000 • 276 citations

Nsec1 Binds a Closed Conformation of Syntaxin1a

2000 • 275 citations

Synaptotagmins form a hierarchy of exocytotic Ca²⁺sensors with distinct Ca²⁺affinities

2002 • 272 citations

Folding intermediates of SNARE complex assembly.

1999 • 272 citations

Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain

1999 • 259 citations

Secretory granule biogenesis: rafting to the SNARE

2001 • 256 citations

The Sec34/35 Golgi Transport Complex Is Related to the Exocyst, Defining a Family of Complexes Involved in Multiple Steps of Membrane Traffic

2001 • 250 citations

The Rab5 Effector EEA1 Interacts Directly with Syntaxin-6

1999 • 247 citations

Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae

1998 • 244 citations

Functional architecture of an intracellular membrane t-SNARE

2000 • 239 citations

Protein phosphorylation and the regulation of synaptic membrane traffic

1999 • 236 citations

Vacuole Fusion at a Ring of Vertex Docking Sites Leaves Membrane Fragments within the Organelle

2002 • 232 citations

Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C2A domain

2002 • 230 citations

Exocytosis: The Many Masters of the Exocyst

2002 • 230 citations

Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p

1998 • 221 citations

Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

2002 • 217 citations

Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin

2001 • 216 citations

Sly1 Binds to Golgi and ER Syntaxins via a Conserved N-Terminal Peptide Motif

2002 • 213 citations

Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity

2002 • 208 citations

N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis

1996 • 206 citations

How Tlg2p/syntaxin 16 'snares' Vps45

2002 • 206 citations

Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115

2002 • 204 citations

Assembly of the ER to Golgi SNARE complex requires Uso1p.

1996 • 203 citations

Control of Fusion Pore Dynamics During Exocytosis by Munc18

2001 • 203 citations

An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes

2001 • 201 citations

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome

1999 • 186 citations

Crystal Structure of the Cytosolic C2a-C2b Domains of Synaptotagmin III

1999 • 174 citations

The Length of the Flexible SNAREpin Juxtamembrane Region Is a Critical Determinant of SNARE-Dependent Fusion

1999 • 173 citations

Selective Interaction of Complexin with the Neuronal SNARE Complex

2000 • 171 citations

synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.

2001 • 169 citations

Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly.

2000 • 167 citations

Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes

2002 • 166 citations

Rabs grab motors: defining the connections between Rab GTPases and motor proteins

2002 • 166 citations

SNAREs and the Secretory Pathway—Lessons from Yeast

1999 • 164 citations

The Class C Vps Complex Functions at Multiple Stages of the Vacuolar Transport Pathway

2001 • 160 citations

The Phosphatidylinositol 3-Phosphate Binding Protein Vac1p Interacts with a Rab GTPase and a Sec1p Homologue to Facilitate Vesicle-mediated Vacuolar Protein Sorting

1999 • 159 citations

Activity-dependent changes in partial VAMP complexes during neurotransmitter release

1999 • 155 citations

Vam3p structure reveals conserved and divergent properties of syntaxins.

2001 • 147 citations

Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation

2001 • 145 citations

Homo- and Heterooligomeric SNARE Complexes Studied by Site-directed Spin Labeling

2001 • 143 citations

synaptotagminMutants Reveal Essential Functions for the C2B Domain in Ca²⁺-Triggered Fusion and Recycling of Synaptic VesiclesIn Vivo

2001 • 142 citations

An Autoinhibitory Mechanism for Nonsyntaxin SNARE Proteins Revealed by the Structure of Ykt6p

2001 • 142 citations

Role of synaptotagmin in Ca2+-triggered exocytosis

2002 • 139 citations

Sec35p, a Novel Peripheral Membrane Protein, Is Required for ER to Golgi Vesicle Docking

1998 • 138 citations

Structure/Function Analysis of Ca²⁺Binding to the C₂A Domain of Synaptotagmin 1

2002 • 137 citations

SNARE-complex disassembly by NSF follows synaptic-vesicle fusion

2001 • 134 citations

Sec34p, a Protein Required for Vesicle Tethering to the Yeast Golgi Apparatus, Is in a Complex with Sec35p

1999 • 131 citations

Vps51p Links the VFT Complex to the SNARE Tlg1p

2002 • 130 citations

Sr2+ Binding to the Ca2+ Binding Site of the Synaptotagmin 1 C2B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions

2003 • 129 citations

Regulation of the UNC-18–Caenorhabditis elegansSyntaxin Complex by UNC-13

1999 • 129 citations

Complexin Regulates the Closure of the Fusion Pore during Regulated Vesicle Exocytosis

2002 • 127 citations

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion

2000 • 120 citations

Synaptic vesicles: is kissing a matter of competence?

2001 • 120 citations

Ras family therapy: Rab, Rho and Ral talk to the exocyst

2002 • 119 citations

NSF N-Terminal Domain Crystal Structure

1999 • 117 citations

SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs

2002 • 117 citations

Membrane Tethering and Fusion in the Secretory and Endocytic Pathways

2000 • 116 citations

Snarepins Are Functionally Resistant to Disruption by Nsf and αSNAP

2000 • 113 citations

Crystal Structure of the Vesicular Transport Protein Sec17

1999 • 112 citations

Structural Analysis of the Neuronal SNARE Protein Syntaxin-1A^,

2000 • 111 citations

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I

2002 • 110 citations

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis

2001 • 110 citations

A cycle of Vam7p release from and PtdIns 3-P–dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion

2002 • 107 citations

Early requirement for alpha -SNAP and NSF in the secretory cascade in chromaffin cells

1999 • 100 citations

Synaptotagmin IX Regulates Ca2+-dependent Secretion in PC12 Cells

2002 • 98 citations

Unraveling the Mechanism of the Vesicle Transport ATPase NSF, the N-Ethylmaleimide-sensitive Factor

2001 • 94 citations

A Novel SNARE N-terminal Domain Revealed by the Crystal Structure of Sec22b

2001 • 94 citations

The N-terminal Domains of Syntaxin 7 and vti1b Form Three-helix Bundles That Differ in Their Ability to Regulate SNARE Complex Assembly

2002 • 75 citations

A t-SNARE of the endocytic pathway must be activated for fusion

2001 • 68 citations

Functional Analysis of Conserved Structural Elements in Yeast Syntaxin Vam3p

2001 • 57 citations

Binding of Sly1 to Sed5 enhances formation of the yeast early Golgi SNARE complex

2002 • 41 citations

The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?

2000 • 28 citations

STEROL SECRETION AND COPROSTEROL FORMATION

1934 • 25 citations

Deleted Work

1955 • 0 citations