Cutting Edge: IL-4-Independent Induction of Airway Hyperresponsiveness by Th2, But Not Th1, Cells

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Bronchoscopic Evaluation of Severe Asthma

1997 • 775 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation

1995 • 686 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?

1993 • 588 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils.

1996 • 440 citations

IL-13 expression at the sites of allergen challenge in patients with asthma.

1995 • 373 citations

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

1995 • 364 citations

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1995 • 342 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

1995 • 311 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

1997 • 275 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

1993 • 259 citations

Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice.

1996 • 207 citations

Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice

1997 • 205 citations

Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma.

1994 • 172 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization.

1994 • 144 citations

Airway hyperreactivity in patients with sarcoidosis.

1981 • 74 citations

Estimation of respiratory parameters by the method of covariance ratios

1974 • 30 citations

LFA-1, and not Mac-1, is crucial for the development of hyperreactivity in a murine model of nonallergic asthma.

1996 • 28 citations

Clonal analysis of lung and blood T cells in patients with sarcoidosis.

1994 • 15 citations

A Role for T Helper-1 Cells in the Induction of Airway Hyperresponsiveness

1993 • 8 citations