Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes

1982 • 1,560 citations

TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

1992 • 1,411 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

1989 • 760 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

Genetic organization of Drosophila bithorax complex

1985 • 514 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia

1987 • 391 citations

CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

1980 • 390 citations

Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less

1992 • 370 citations

GENES AND DEVELOPMENTAL PATHWAYS

1963 • 366 citations

Molecular and Genetic Organization of The Antennapedia Gene Complex of Drosophila melanogaster

1990 • 360 citations

Genes controlling segmental specification in the Drosophila thorax.

1982 • 360 citations

[33] High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors

1991 • 350 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

Induction across germ layers in Drosophila mediated by a genetic cascade

1990 • 342 citations

The molecular organization of the Antennapedia locus of drosophila

1983 • 331 citations

THE BITHORAX COMPLEX

1987 • 326 citations

Analysis of larval segmentation in lethal genotypes associated with the Antennapedia gene complex in Drosophila melanogaster

1981 • 325 citations

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

1992 • 289 citations

HNF-1, a member of a novel class of dimerizing homeodomain proteins.

1991 • 286 citations

Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos

1990 • 265 citations

Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice

1989 • 262 citations

Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster

1984 • 259 citations

Functional dissection of ultrabithorax proteins in D. melanogaster

1990 • 255 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

1990 • 239 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein

1991 • 225 citations

a1 Protein alters the dna binding specificity of α2 repressor

1988 • 218 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs

1991 • 208 citations

Spatial distribution of Antennapedia transcripts during Drosophila development.

1983 • 191 citations

The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain

1990 • 189 citations

The localization and regulation of Antennapedia protein expression in Drosophila embryos

1986 • 186 citations

The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products

1990 • 178 citations

Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

1990 • 170 citations

A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer

1992 • 170 citations

Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.

1989 • 158 citations

The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo

1992 • 157 citations

Are cross-regulatory interactions between homoeotic genes functionally significant?

1990 • 148 citations

Head and thoracic transformations caused by ectopic expression ofAntennapediaduringDrosophiladevelopment

1988 • 147 citations

The interaction with DNA of wild-type and mutant fushi tarazu homeodomains.

1990 • 142 citations

Alternative RNA products from the Ultrabithorax domain of the bithorax complex.

1988 • 135 citations

Organogenesis in Drosophila melanogaster. embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes

1992 • 135 citations

Mapping functional specificity in the Dfd and Ubx homeo domains.

1992 • 134 citations

A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

1992 • 134 citations

The role of the teashirt gene in trunk segmental identity in Drosophila

1992 • 132 citations

The Oct-2 protein binds cooperatively to adjacent octamer sites.

1989 • 132 citations

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

1991 • 128 citations

Homeotic gene expression in the visceral mesoderm of Drosophila embryos.

1989 • 128 citations

The expression and regulation of Sex combs reduced protein in Drosophila embryos.

1987 • 127 citations

Expression and function of the homoeotic genes Antennapedia and Sex combs reduced in the embryonic midgut of Drosophila

1990 • 125 citations

Molecular analysis of the dominant homeotic Antennapedia phenotype

1987 • 117 citations

The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.

1993 • 116 citations

Recognition of the surface of a homeo domain protein.

1992 • 115 citations

Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

1992 • 113 citations

The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development.

1991 • 111 citations

Structure of transcripts from the homeotic Antennapedia gene of Drosophila melanogaster: two promoters control the major protein-coding region.

1986 • 107 citations

High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.

1991 • 99 citations

An autoregulatory enhancer element of the Drosophila homeotic gene Deformed.

1990 • 96 citations

An inversion that disrupts the Antennapedia gene causes abnormal structure and localization of RNAs

1986 • 96 citations

Distribution of the Sex combs reduced Gene Products in Drosophila melanogaster

1987 • 95 citations

Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts

1985 • 87 citations

REVERTANTS OF DOMINANT MUTATIONS ASSOCIATED WITH THE ANTENNAPEDIA GENE COMPLEX OF DROSOPHILA MELANOGASTER: CYTOLOGY AND GENETICS

1983 • 83 citations

Developmental studies of lethality associated with the Antennapedia gene complex in Drosophila melanogaster

1981 • 80 citations

The Antennapedia gene is required and expressed in parasegments 4 and 5 of the Drosophila embryo

1986 • 77 citations

Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia.

1992 • 75 citations

Downstream of the homeotic genes.

1992 • 74 citations

Expression of the Sex combs reduced protein in Drosophila larvae

1988 • 61 citations

Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system

1992 • 59 citations

Homoeosis in Drosophila: Roles and spatial patterns of expression of the Antennapedia and Sex combs reduced loci in embryogenesis

1985 • 56 citations

Developmentally regulated alternative splicing of transcripts from the Drosophila homeotic gene Antennapedia can produce four different proteins.

1988 • 53 citations

Structural basis for the nucleic acid binding cooperativity of bacteriophage T4 gene 32 protein: the (Lys/Arg)3(Ser/Thr)2 (LAST) motif.

1992 • 41 citations

Misregulation of homeotic gene expression in Drosophila larvae resulting from mutations at the extra sex combs locus

1988 • 39 citations

The developmental autonomy of extra sex combs in Drosophila melanogaster

1965 • 39 citations

Alternative RNA splicing that is spatially regulated: generation of transcripts from the Antennapedia gene of Drosophila melanogaster with different protein-coding regions.

1988 • 31 citations

Homeotic transformation of thorax into head: Developmental analysis of a new Antennapedia allele in Drosophila melanogaster

1985 • 28 citations