Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

The Hallmarks of Cancer

2000 • 27,569 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Tumorigenesis and the angiogenic switch

2003 • 3,398 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Role of angiogenesis in tumor growth and metastasis

2002 • 2,412 citations

Role of angiogenesis in tumor growth and metastasis

2002 • 2,310 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

2005 • 1,985 citations

Genesis: cluster analysis of microarray data

2002 • 1,737 citations

Models, mechanisms and clinical evidence for cancer dormancy

2007 • 1,523 citations

Interferons, immunity and cancer immunoediting

2006 • 1,497 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 • 1,175 citations

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

1996 • 1,110 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

IL-1 is required for tumor invasiveness and angiogenesis

2003 • 986 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

1999 • 833 citations

Cancer Immunology

2008 • 733 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

2002 • 580 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch

2006 • 483 citations

Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

2006 • 443 citations

The Adaptive Immunologic Microenvironment in Colorectal Cancer: A Novel Perspective

2007 • 416 citations

Humoral immunity, inflammation and cancer

2007 • 403 citations

Combined Functional Genomic Maps of the C. elegans DNA Damage Response

2002 • 279 citations

Vascular Endothelial Growth Factor and Its Relationship to Inflammatory Mediators

2007 • 269 citations

Cytokines and Immune Response in the Tumor Microenvironment

2001 • 250 citations

Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells

2003 • 232 citations

Increased rejection of primary tumors in mice lacking B cells: Inhibition of anti-tumor CTL and TH1 cytokine responses by B cells

2005 • 215 citations

Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability

2004 • 214 citations

Immunology and immunotherapy of colorectal cancer

2003 • 130 citations

Reciprocal Changes in Tumor Antigenicity and Antigen-specific T Cell Function during Tumor Progression

2004 • 102 citations

Tumor cell dormancy: An NCI workshop report

2007 • 102 citations

Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma

2003 • 102 citations

T Cell Memory Against Colon Carcinoma Is Long-Lived in the Absence of Antigen

1999 • 51 citations

Prognostic factors and clinical trials of new agents in patients with metastatic renal cell carcinoma

2003 • 33 citations

Analysis of the T Cell Receptor Variability of Tumor-Infiltrating Lymphocytes in Colorectal Carcinomas

1998 • 31 citations

Does the EGFR and VEGF Expression Predict the Prognosis in Colon Cancer?

2006 • 28 citations