Reciprocal Changes in Tumor Antigenicity and Antigen-specific T Cell Function during Tumor Progression

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

A Critical Role for Stat3 Signaling in Immune Tolerance

2003 • 388 citations

CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

1999 • 378 citations

Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity

2000 • 337 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Modelling T-cell memory by genetic marking of memory T cells in vivo

1999 • 310 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

HLA class I antigen abnormalities and immune escape by malignant cells

2002 • 264 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells

2002 • 239 citations

Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells

2003 • 219 citations

Cross-presentation of tumor antigens by bone marrow–derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

2001 • 214 citations

Maintenance of in Vivo Tolerance by Persistence of Antigen

1992 • 209 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4⁺ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

1996 • 165 citations

Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen

2000 • 160 citations

Control of Syngeneic Tumor Growth by Activation of CD8+ T Cells: Efficacy Is Limited by Migration Away from the Site and Induction of Nonresponsiveness

1999 • 146 citations

Innate Immune Induction of the Adaptive Immune Response

1999 • 145 citations

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

2002 • 129 citations

Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens.

2003 • 124 citations

Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation?

1991 • 105 citations

Memory CD8+ T Cells Undergo Peripheral Tolerance

2002 • 84 citations

A Spontaneously Arising Pancreatic Tumor Does Not Promote the Differentiation of Naive CD8+ T Lymphocytes into Effector CTL

2004 • 74 citations

Tolerance and Cancer: A Critical Issue in Tumor Immunology

1996 • 73 citations

CD4+ T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance Induction

2003 • 72 citations

Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation

2003 • 56 citations

Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells

2003 • 47 citations

Deletion of Naive CD8 T Cells Requires Persistent Antigen and Is Not Programmed by an Initial Signal from the Tolerogenic APC

2003 • 38 citations

Effector CD4 Cells Are Tolerized Upon Exposure to Parenchymal Self-Antigen

2002 • 35 citations

The therapeutic significance of concomitant antitumor immunity

1984 • 27 citations

The therapeutic significance of concomitant antitumor immunity

1984 • 19 citations

Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors

1985 • 18 citations

Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-α and IFN-γ expression potentials

2003 • 16 citations