Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Regression Models and Life-Tables

1992 • 27,454 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

BMDP Statistical Software 1981.

1984 • 5,347 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin.

1986 • 391 citations

The role of proteolytic enzymes in cancer invasion and metastasis

1992 • 372 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma.

1993 • 192 citations

Enhanced production of matrix metalloproteinases and activation of matrix metalloproteinase 2 (gelatinase A) in human gastric carcinomas

1996 • 170 citations

Urokinase and plasminogen activator inhibitor type 1 in pulmonary adenocarcinoma

1994 • 169 citations

Effective activation of the proenzyme form of the urokinase‐type plasminogen activator (pro‐uPA) by the cysteine protease cathepsin L

1992 • 157 citations

Receptor‐mediated endocytosis of plasminogen activators and activator/inhibitor complexes

1994 • 148 citations

The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma.

1991 • 147 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Immunohistochemical localization of matrix metallloproteinase 2 and its specific inhibitor timp‐2 in neoplastic tissues with monclonal antibodies

1994 • 137 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.

1995 • 116 citations

Prognosis of gastric carcinoma revealed by interactions between tumor cells and basement membrane.

1994 • 93 citations

Structure and function of the urokinase receptor

1993 • 80 citations

Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness

1995 • 67 citations

Serum acute phase reactants and prognosis in renal cell carcinoma

1995 • 65 citations

Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach.

1993 • 59 citations

Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer

1993 • 54 citations

Alpha-1-antichymotrypsin expression in lung adenocarcinoma and its possible association with tumor progression

1995 • 45 citations

Plasminogen activators in human gastric cancers: Correlation with DNA ploidy and immunohistochemical staining

1991 • 38 citations

Defining the invasive phenotype of proximal gastric cancer cells

1994 • 36 citations

?2-Macroglobulin is mainly produced by cancer cells and not by hepatocytes in rats with colon carcinoma metastases in liver

1996 • 34 citations

The prognostic impact of the urokinase-type plasminogen activator system is associated with tumour differentiation in gastric cancer

1996 • 30 citations

Secretion of α2-macroglobulin, α2-antiplasmin, and plasminogen activator inhibitor-1 by glioblastoma multiforme in primary organ culture

1990 • 25 citations

Structural and functional characterization of the inhibition of urokinase by .alpha.2-macroglobulin

1985 • 25 citations

Tumor‐associated alpha‐2‐macroglobulin in human melanomas

1988 • 24 citations

In situ hybridization studies of α2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma

1996 • 21 citations

Relationship Between Plasminogen Activators and Stomach Carcinoma Stage

1991 • 21 citations

Deleted Work

1955 • 0 citations