Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

On the Regulation and Control of Fibrinolysis

1980 • 1,139 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Cancer of the pancreas: 50 years of surgery

1987 • 627 citations

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors

1987 • 625 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.

1993 • 413 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage.

1993 • 321 citations

Expression and in‐situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer

1995 • 234 citations

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

1984 • 229 citations

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

1994 • 225 citations

Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer.

1994 • 187 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

The c‐erbB‐2 proto‐oncogene in human pancreatic cancer

1990 • 172 citations

Urokinase and plasminogen activator inhibitor type 1 in pulmonary adenocarcinoma

1994 • 169 citations

Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

1993 • 165 citations

Induction and expression of amphiregulin in human pancreatic cancer.

1994 • 160 citations

The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.

1994 • 153 citations

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

1995 • 150 citations

Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.

1993 • 145 citations

Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors

1996 • 140 citations

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1994 • 139 citations

Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors.

1992 • 137 citations

Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression.

1995 • 137 citations

Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: comparison with urokinase levels.

1993 • 102 citations

Primary tumor and metastasis in ovarian cancer differ in their content of urokinase-type plasminogen activator, its receptor, and inhibitors types 1 and 2.

1995 • 96 citations

Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers

1993 • 92 citations

Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies.

1994 • 60 citations

Expression of plasminogen activators and their inhibitors in human pancreatic carcinoma: immunohistochemical study.

1993 • 56 citations

Growth factor-like effect of urokinase type plasminogen activator in human renal cells

1991 • 43 citations

Plasminogen activators in human gastric cancers: Correlation with DNA ploidy and immunohistochemical staining

1991 • 38 citations

Comparison of the immunohistochemical localisation of urokinase in normal and cancerous human colon tissue

1989 • 15 citations

Prognosis in Carcinoma of the Pancreas

1994 • 4 citations