Erection Capability Is Potentiated by Long-Term Sildenafil Treatment: Role of Blood Flow-Induced Endothelial Nitric-Oxide Synthase Phosphorylation

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

1990 • 854 citations

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle

2000 • 599 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

1999 • 536 citations

Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase

1999 • 522 citations

The Akt kinase signals directly to endothelial nitric oxide synthase

1999 • 469 citations

Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells

2002 • 399 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection

2002 • 368 citations

Nitric Oxide in the Penis: Physiology and Pathology

1997 • 352 citations

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction

2004 • 305 citations

Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway

2001 • 304 citations

Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease

2003 • 255 citations

Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism

2005 • 241 citations

Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells

1998 • 198 citations

Inhibition of Cyclic GMP-Binding Cyclic GMP-Specific Phosphodiesterase (Type 5) by Sildenafil and Related Compounds

1999 • 193 citations

RhoA-mediated Ca2+ Sensitization in Erectile Function

2002 • 169 citations

Novel nitric oxide signaling mechanisms regulate the erectile response

2004 • 151 citations

Chronic Sildenafil Improves Erectile Function and Endothelium-dependent Cavernosal Relaxations in Rats: Lack of Tachyphylaxis

2004 • 133 citations

Effect of aging on nitric oxide-mediated penile erection in rats

1995 • 130 citations

Cloning of Rat and Human Inducible Penile Nitric Oxide Synthase. Application for Gene Therapy of Erectile Dysfunction1

1997 • 125 citations

Aging-Related Expression of Inducible Nitric Oxide Synthase and Markers of Tissue Damage in the Rat Penis1

2001 • 109 citations

Gene Therapy of Erectile Dysfunction in the Rat with Penile Neuronal Nitric Oxide Synthase1

2002 • 108 citations

Sildenafil in erectile dysfunction: a critical review

2003 • 101 citations

Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase β

2003 • 98 citations

Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters

2002 • 95 citations

ROLE OF BRADYKININ IN THE NEONATAL RENAL EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITION

1997 • 94 citations

Up and Down-Regulation of Phosphodiesterase-5 as Related to Tachyphylaxis and Priapism

2003 • 78 citations

[³H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

2003 • 78 citations

Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection

2002 • 77 citations

Age-Related Changes in Phosphorylation of Endothelial Nitric Oxide Synthase in the Rat Penis

2005 • 76 citations

Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time

2003 • 72 citations

Phosphorylated Endothelial Nitric Oxide Synthase Mediates Vascular Endothelial Growth Factor-Induced Penile Erection1

2004 • 67 citations

The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit

2001 • 65 citations

Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats

2004 • 64 citations

THE EFFECT OF SILDENAFIL ON APOMORPHINE-EVOKED INCREASES IN INTRACAVERNOUS PRESSURE IN THE AWAKE RAT

1999 • 55 citations

IN VIVO AND IN VITRO INVESTIGATION OF THE EFFECTS OF SILDENAFIL ON RAT CAVERNOUS SMOOTH MUSCLE

2001 • 25 citations

The effect of sildenafil on electrostimulation-induced erection in the rat model

2002 • 15 citations

Vasoactive pharmacotherapy to cure erectile dysfunction: Fact or fiction?

2005 • 11 citations