Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

1992 • 1,028 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Sildenafil for Treatment of Erectile Dysfunction in Men With Diabetes

1999 • 616 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Oral sildenafil in the treatment of erectile dysfunction

2002 • 406 citations

Role of Nitric Oxide in the Physiology of Erection1

1995 • 259 citations

Increased Expression of Arginase II in Human Diabetic Corpus Cavernosum: In Diabetic-Associated Erectile Dysfunction

2001 • 211 citations

Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.

1995 • 182 citations

DIABETIC SEXUAL DYSFUNCTION

1996 • 179 citations

Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus

2001 • 160 citations

Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat

1999 • 153 citations

CLINICAL EFFICACY OF SILDENAFIL CITRATE BASED ON ETIOLOGY AND RESPONSE TO PRIOR TREATMENT

1999 • 148 citations

SILDENAFIL, A TYPE-5 CGMP PHOSPHODIESTERASE INHIBITOR, SPECIFICALLY AMPLIFIES ENDOGENOUS cGMP-DEPENDENT RELAXATION IN RABBIT CORPUS CAVERNOSUM SMOOTH MUSCLE IN VITRO

1998 • 146 citations

SILDENAFIL CITRATE AFTER RADICAL RETROPUBIC PROSTATECTOMY

1999 • 136 citations

F-actin disruption attenuates agonist-induced [Ca2+], myosin phosphorylation, and force in smooth muscle

1997 • 129 citations

Gene Transfer of Endothelial Nitric Oxide Synthase Improves Relaxation of Carotid Arteries From Diabetic Rabbits

2000 • 122 citations

Sildenafil Citrate, a Selective Phosphodiesterase Type 5 Inhibitor:

1999 • 121 citations

Gene transfer of extracellular SOD to the penis reduces O 2 − · and improves erectile function in aged rats

2003 • 113 citations

Pharmacotherapy for erectile dysfunction

2000 • 112 citations

Gene Therapy of Erectile Dysfunction in the Rat with Penile Neuronal Nitric Oxide Synthase1

2002 • 108 citations

Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model

1999 • 106 citations

Diminished neurogenic but not pharmacological erections in the 2- to 3-month experimentally diabetic F-344 rat

1997 • 97 citations

Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters

2002 • 95 citations

Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat

2000 • 92 citations

Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog.

1998 • 86 citations

Gene Transfer of Prepro-Calcitonin Gene-Related Peptide Restores Erectile Function in the Aged Rat1

2001 • 81 citations

Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction

2001 • 79 citations

EFFECT OF THE SELECTIVE PHOSPHODIESTERASE TYPE 5 INHIBITOR SILDENAFIL ON ERECTILE FUNCTION IN THE ANESTHETIZED DOG

1998 • 76 citations

Endothelial Nitric Oxide Synthase Protein Expression, Localization, and Activity in the Penis of the Alloxan-Induced Diabetic Rat

2001 • 72 citations

Nitric Oxide and the Cyclic GMP System in the Penis.

1999 • 69 citations

PATHOPHYSIOLOGY OF HYPERTENSION AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DIABETES MELLITUS

2001 • 67 citations

The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit

2001 • 65 citations

Nitric Oxide Synthase Gene Therapy for Erectile Dysfunction: Comparison of Plasmid, Adenovirus, and Adenovirus-Transduced Myoblast Vectors

2001 • 42 citations

Potential Application of Gene Therapy for the Treatment of Erectile Dysfunction

2001 • 39 citations

Gene transfer of endothelial nitric oxide synthase alters endothelium-dependent relaxations in aortas from diabetic rabbits

2000 • 35 citations

American Diabetes Association Annual Meeting, 1997: Endothelial dysfunction, neuropathy and the diabetic foot, diabetic mastopathy and erectile dysfunction

1998 • 29 citations

Impaired endothelium-dependent and neurogenic relaxation of corpus cavernosum from diabetic rats: improvement with L -arginine

2000 • 29 citations

IN VIVO AND IN VITRO INVESTIGATION OF THE EFFECTS OF SILDENAFIL ON RAT CAVERNOUS SMOOTH MUSCLE

2001 • 25 citations

The effects of diabetes on nitric oxide-mediated responses in rat corpus cavernosum

1999 • 22 citations