The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Transforming growth factor beta

2011 • 1,990 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Identification and characterization of a fibroblast marker: FSP1.

1995 • 1,050 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

The Progression of Renal Disease

1988 • 840 citations

Transforming Growth Factor‐β

1990 • 696 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Molecular insights into renal interstitial fibrosis.

1996 • 636 citations

The Nature and Significance of Osteopontin

1989 • 561 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

1995 • 536 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

1997 • 406 citations

Cellular events in the evolution of experimental diabetic nephropathy

1995 • 320 citations

mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

1993 • 300 citations

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

1997 • 300 citations

Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

1993 • 295 citations

Transforming Growth Factor β

1988 • 295 citations

Mechanisms of tubulointerstitial fibrosis

1991 • 291 citations

Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes

1997 • 275 citations

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

1990 • 246 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats

1994 • 208 citations

Mechanisms for Inducible Control of Angiotensinogen Gene Transcription

1996 • 202 citations

Requirements for leukocyte adhesion molecules in nephrotoxic nephritis.

1993 • 197 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products

1995 • 175 citations

Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin).

1994 • 163 citations

A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB

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Evidence for the central role of glomerular growth promoters in the development of sclerosis.

1989 • 154 citations

Nitric oxide generation ameliorates the tubulointerstitial fibrosis of obstructive nephropathy.

1996 • 138 citations

Angiotensin II and gene expression in the kidney

1998 • 128 citations

Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms

1999 • 128 citations

Potential Role of an Endothelium-Specific Growth Factor, Hepatocyte Growth Factor, on Endothelial Damage in Diabetes

1997 • 126 citations

The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis.

1997 • 125 citations

Up-regulation of hepatocyte growth factor receptor: An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure

1999 • 121 citations

Enalapril decreases nuclear factor κB activation in the kidney with ureteral obstruction: Rapid Communication

1997 • 118 citations

Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney

1990 • 112 citations

Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia

1991 • 111 citations

Angiotensinogen gene activation by angiotensin II is mediated by the rel A (nuclear factor-kappaB p65) transcription factor: one mechanism for the renin angiotensin system positive feedback loop in hepatocytes.

1996 • 100 citations

Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen

1995 • 99 citations

Tumor Necrosis Factor Activates Angiotensinogen Gene Expression by the Rel A Transactivator

1996 • 96 citations

TNFα induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells

1993 • 91 citations

Tumor necrosis factor alpha and mesangial cells

1992 • 84 citations

Octreotide administration in diabetic rats: Effects on renal hypertrophy and urinary albumin excretion

1992 • 83 citations

Enhanced Expression of Platelet-Derived Growth Factor-β Receptor by High Glucose Involvement of Platelet-Derived Growth Factor in Diabetic Angiopathy

1996 • 77 citations

Proliferation of renal interstitial cells following injury induced by ureteral obstruction.

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The growth hormone-insulin-like growth factor axis in kidney

1989 • 72 citations

Involvement of tumor necrosis factor-alpha in the pathogenesis of experimental and human glomerulonephritis.

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Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways

1997 • 64 citations

Growth factors and glomerular sclerosis.

1992 • 50 citations

Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy

1997 • 47 citations

The expression of mRNA for tumour necrosis factor‐α increases in the obstructed kidney of rats soon after unilateral ureteral ligation

1996 • 45 citations

Tissue factor expression in an animal model of hydronephrosis

1995 • 42 citations

The growth hormone-insulin-like growth factor axis in kidney

1989 • 38 citations

In vivo and in vitro evidence for increased expression of HGF receptor in kidney of diabetic rat

1996 • 37 citations

A κB-related Binding Site Is an Integral Part of the mts1 Gene Composite Enhancer Element Located in the First Intron of the Gene

1997 • 31 citations

Regulation of endothelin production and secretion in cultured collecting duct cells by endogenous transforming growth factor-beta.

1996 • 29 citations

Increased Gene Expression of Insulin-Like Growth Factor-I Receptor in Experimental Diabetic Rat Glomeruli

1996 • 26 citations

Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells

1997 • 25 citations

Role of insulin and IGF1 receptors in proliferation of cultured renal proximal tubule cells

1992 • 24 citations

The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels

1995 • 9 citations

Perspectives in Diabetes Hyperglycemia and Diabetic Kidney Disease The Case for Transforming Growth Factor-P as a Key

1995 • 1 citations