Conformation of promoter DNA: Fine mapping of S1-hypersensitive sites

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

[31] Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids

1971 • 1,605 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

E. coli RNA polymerase interacts homologously with two different promoters

1980 • 911 citations

Purification and Further Properties of Single‐Strand‐Specific Nuclease from Aspergillus oryzae

1973 • 862 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Active chromatin

1982 • 549 citations

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences

1983 • 477 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

DNA flexibility studied by covalent closure of short fragments into circles.

1981 • 456 citations

An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin

1982 • 448 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

Visualization of drug-nucleic acid interactions at atomic resolution

1977 • 276 citations

A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin

1983 • 273 citations

[10] Elution of DNA from agarose gels after electrophoresis

1979 • 266 citations

Homocopolymer sequences in the spacer of a sea urchin histone gene repeat are sensitive to S1 nuclease

1982 • 220 citations

Transcription of DNA injected into Xenopus oocytes is influenced by template topology

1983 • 219 citations

Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions

1983 • 212 citations

Specificity of the S1 nuclease from Aspergillus oryzae.

1975 • 201 citations

Agarose slab-gel electrophoresis equipment

1975 • 201 citations

DNA Structure and Gene Regulation

1980 • 200 citations

Transposon-mediated site-specific recombination in vitro: DNA cleavage and protein-DNA linkage at the recombination site

1981 • 172 citations

Association of an S1 nuclease-sensitive structure with short direct repeats 5′ of Drosophila heat shock genes

1983 • 171 citations

DNA supercoiling: Another level for regulating gene expression

1981 • 166 citations

[48] A general method for defining restriction enzyme cleavage and recognition sites

1980 • 123 citations

Delimitation of far upstream sequences required for maximal in vitro transcription of an H2A histone gene.

1982 • 119 citations

Visualization of drug--nucleic acid interactions at atomic resolution. VI. Structure of two drug--dinucleoside monophosphate crystalline complexes, ellipticine--5-iodocytidylyy (3'-5') guanosine and 3,5,6,8-tetramethyl-N-methyl phenanthrolinium--5-iodocytidylyl (3'-5') guanosine.

1979 • 110 citations

Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.

1983 • 109 citations

[38] Fractionation of low molecular weight DNA or RNA in polyacrylamide gels containing 98% formamide or 7 M urea

1980 • 108 citations

[6] Specific labeling of 3′ termini with T4 DNA polymerase

1980 • 102 citations

Multiple origins of transcription in the 4.5 Kb upstream of the ϵ-globin gene

1983 • 98 citations

Duplex regions in "single-stranded" phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius.

1977 • 85 citations

The lac Promoter

1980 • 78 citations

[32] Purification and properties of S1 nuclease from Aspergillus

1980 • 73 citations

DNA sequence changes in an upstream DNase I-hypersensitive region are correlated with reduced gene expression.

1983 • 71 citations

Structure of the Operator-binding Domain of Bacteriophage Repressor: Implications for DNA Recognition and Gene Regulation

1983 • 65 citations

Sites Required for Position-Effect Regulation of Mating-type Information in Yeast

1983 • 64 citations

-Kinked DNA--a Structure That Gives Rise to Drug Intercalation and DNA Breathing--and Its Wider Significance in Determining the Premelting and Melting Behavior of DNA

1983 • 57 citations

S1 sensitive sites in adenovirus DNA

1983 • 56 citations

A catalogue of cleavages of ∅X174, S13, G4, and ST-1 DNA by 26 different restriction endonucleases

1976 • 45 citations

Catabolite Gene Activator Protein: Structure, Homology with Other Proteins, and Cyclic AMP and DNA Binding

1983 • 45 citations

Chromatin structure, DNA structure

1982 • 44 citations

Cro Repressor Protein and Its Interaction with DNA

1983 • 37 citations

[33] Purification and properties of Neurospora crassa Endo-exonuclease, an Enzyme which can be converted to a single-strand specific endonuclease

1980 • 35 citations

5' Domain and nucleotide sequence of an adult chicken chromosomal .beta.-globin gene

1981 • 29 citations

[25] DNA ligase from Escherichia coli infected with bacteriophage T4

1971 • 22 citations

DNA Supercoiling: Changes during Cellular Differentiation and Activation of Chromatin Transcription

1983 • 18 citations

S1 nuclease of Aspergillus oryzae.

1981 • 12 citations

Cleavage of "single-stranded" viral DNAs by certain restriction endonucleases.

1981 • 11 citations

DNA Formed by Reassociation of Complementary Single-stranded Circles from Natural DNA Is Shown to Contain Left- and Right-handed Double Helices

1983 • 10 citations