Lymphocytes infiltrating colorectal cancer have low proliferative capacity but can secrete normal levels of interferon γ

Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.

1986 • 319 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Local expression of antiinflammatory cytokines in cancer.

1993 • 198 citations

Lymphoid infiltration and prognosis in colorectal carcinoma

1984 • 190 citations

Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells.

1991 • 159 citations

T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.

1993 • 158 citations

The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor‐infiltrating lymphocytes

1994 • 115 citations

The Transforming Growth Factor‐Betas: A New Family of Immunoregulatory Molecules

1990 • 103 citations

Characterization of a Human Renal Cell Carcinoma Specific Cytotoxic CD8+ T Cell Line

1992 • 100 citations

Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer.

1994 • 100 citations

T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone.

1993 • 98 citations

Human cytotoxic T-cell lines with restricted specificity for squamous cell carcinoma of the head and neck.

1993 • 95 citations

Specific immune recognition of autologous tumor by lymphocytes infiltrating colon carcinomas: Analysis by cytokine secretion

1993 • 69 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion

1995 • 59 citations

Different immune functions of peripheral blood, regional lymph node, and tumor infiltrating lymphocytes in lung cancer patients

1988 • 47 citations

Functional characterization of tumor‐infiltrating lymphocytes, lymph‐node lymphocytes and peripheral‐blood lymphocytes from patients with breast cancer

1991 • 44 citations

Frequency of abnormal expression of HLA-A,B,C and HLA-DR molecules, invariant chain, and LFA-3 (CD58) in colorectal carcinoma and its impact on tumor recurrence

1991 • 40 citations

Human colorectal tumour infiltrating lymphocytes express activation markers and the CD45RO molecule, showing a primed population of lymphocytes in the tumour area.

1994 • 36 citations

Cea expression of colorectal adenocarcinomas is correlated with their resistance against lak‐cell lysis

1994 • 35 citations

Prostaglandin E2 levels and lymphocyte subsets in portal venous drainage of colorectal cancers

1994 • 31 citations

Functional evaluation of tumor-infiltrating mononuclear cells. Detection of endogenous interferon-γ and tumor necrosis factor-α in human colorectal adenocarcinomas

1991 • 26 citations

The analysis of mononuclear cell infiltrations in colorectal adenocarcinoma

1985 • 25 citations

Characterization of activated lymphocytes in colon cancer

1989 • 23 citations

The cellular response to human colonic neoplasms: Macrophage numbers

1983 • 19 citations

Limited heterogeneity in the T-cell receptor V-gene usage in lymphocytes infiltrating human colorectal tumours

1994 • 11 citations

The major histocompatibility complex: Its genes and their roles in antigen presentation

1994 • 10 citations

Lymphoreticular cells within primary colorectal carcinoma: A surface marker study

1981 • 9 citations

Analysis of T‐cell‐receptor variable gene segment usage in peripheral‐blood lymphocytes of advanced cancer patients

1993 • 7 citations

Activation by interferon- of expression of ICAM-1 and MHC class II antigens in tumour cells from colorectal carcinomas

1995 • 3 citations

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