NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

HSP90 and the chaperoning of cancer

2005 • 2,352 citations

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

2003 • 1,356 citations

Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery

2006 • 1,058 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

2002 • 633 citations

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

2004 • 557 citations

Drugging the Cancer Chaperone HSP90

2007 • 511 citations

Molecular chaperones and the stress of oncogenesis

2004 • 507 citations

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

2005 • 489 citations

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

2002 • 427 citations

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

2007 • 424 citations

DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90

1999 • 352 citations

Combination of Trastuzumab and Tanespimycin (17-AAG, KOS-953) Is Safe and Active in Trastuzumab-Refractory HER-2–Overexpressing Breast Cancer: A Phase I Dose-Escalation Study

2007 • 334 citations

High HSP90 Expression Is Associated with Decreased Survival in Breast Cancer

2007 • 332 citations

Inhibitors of the HSP90 Molecular Chaperone: Current Status

2006 • 313 citations

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

2005 • 306 citations

Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

2001 • 281 citations

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

2003 • 275 citations

Activated B-RAF Is an Hsp90 Client Protein That Is Targeted by the Anticancer Drug 17-Allylamino-17-Demethoxygeldanamycin

2005 • 243 citations

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

2005 • 231 citations

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

2003 • 226 citations

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

2005 • 221 citations

Hypoxia‐inducible factor‐1 and oncogenic signalling

2004 • 207 citations

Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells

2007 • 207 citations

Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90

2006 • 184 citations

Pharmacokinetic-Pharmacodynamic Relationships for the Heat Shock Protein 90 Molecular Chaperone Inhibitor 17-Allylamino, 17-Demethoxygeldanamycin in Human Ovarian Cancer Xenograft Models

2005 • 166 citations

Targeting Wide-Range Oncogenic Transformation via PU24FCl, a Specific Inhibitor of Tumor Hsp90

2004 • 165 citations

Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases

2004 • 162 citations

The Heat Shock Protein 90 Inhibitor, 17-Allylamino-17-demethoxygeldanamycin, Enhances Osteoclast Formation and Potentiates Bone Metastasis of a Human Breast Cancer Cell Line

2005 • 144 citations

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin

2004 • 139 citations

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

2007 • 139 citations

Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

2007 • 139 citations

Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations.

1998 • 132 citations

Heat Shock Protein 90 Inhibitors. A Text Book Example of Medicinal Chemistry?

2005 • 125 citations

7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors

2006 • 113 citations

In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

2007 • 110 citations

Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities

2002 • 109 citations

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

2006 • 108 citations

Induction of heat shock proteins by heregulin β1 leads to protection from apoptosis and anchorage-independent growth

2005 • 106 citations

Hsp90 Inhibitors in the Clinic

2005 • 96 citations

Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT

2006 • 94 citations

Circulating Epstein-Barr virus DNA in serum of patients with lymphoepithelioma-like carcinoma of the lung: a potential surrogate marker for monitoring disease.

2002 • 81 citations

A fluorescence polarization assay for inhibitors of Hsp90

2006 • 80 citations

Targeting chaperones in transformed systems – a focus on Hsp90 and cancer

2006 • 77 citations

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

2006 • 77 citations

Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors

2004 • 73 citations

Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90

2005 • 71 citations

Establishment of an Isogenic Human Colon Tumor Model forNQO1Gene Expression: Application to Investigate the Role of DT-Diaphorase in Bioreductive Drug Activation In Vitro and In Vivo

2000 • 70 citations

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins

2003 • 65 citations

Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion

2005 • 52 citations

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors

2006 • 38 citations