The Heat Shock Protein 90 Inhibitor, 17-Allylamino-17-demethoxygeldanamycin, Enhances Osteoclast Formation and Potentiates Bone Metastasis of a Human Breast Cancer Cell Line

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Mechanisms of Bone Metastasis

2004 • 2,680 citations

Metastasis to bone: causes, consequences and therapeutic opportunities

2002 • 2,661 citations

A multigenic program mediating breast cancer metastasis to bone

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The microenvironment of the tumour–host interface

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

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Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

General mechanisms of metastasis

1997 • 610 citations

Heat shock protein 90 as a molecular target for cancer therapeutics

2003 • 572 citations

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

2004 • 557 citations

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

2002 • 526 citations

A Bone-Seeking Clone Exhibits Different Biological Properties from the MDA-MB-231 Parental Human Breast Cancer Cells and a Brain-Seeking Clone In Vivo and In Vitro

2001 • 459 citations

Osteotropic Agents Regulate the Expression of Osteoclast Differentiation Factor and Osteoprotegerin in Osteoblastic Stromal Cells

1998 • 444 citations

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

2002 • 427 citations

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

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Heat shock protein 90

2003 • 397 citations

American Society of Clinical Oncology Guideline on the Role of Bisphosphonates in Breast Cancer

2000 • 388 citations

More than folding: localized functions of cytosolic chaperones

2003 • 375 citations

DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90

1999 • 352 citations

Seed and Soil

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Altered Hsp90 function in cancer: A unique therapeutic opportunity

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?Seed and soil? revisited: mechanisms of site-specific metastasis

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Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

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Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1)

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2

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Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions

2001 • 269 citations

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

2000 • 260 citations

Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.

1997 • 250 citations

Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5

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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

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Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism.

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Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

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The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells

1996 • 223 citations

Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo.

2002 • 211 citations

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone

2000 • 200 citations

C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis.

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The Biochemistry of Cancer Dissemination

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Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers

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Management of Bone Metastases

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Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway.

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Factors regulating the growth of metastatic cancer in bone.

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Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

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Development of Radicicol Analogues

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Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.

2003 • 103 citations

17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models

2004 • 88 citations

Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.

2003 • 83 citations

Pro-Matrix Metalloproteinase-2 Transfection Increases Orthotopic Primary Growth and Experimental Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude Mice

2004 • 82 citations

Expression of the Insulin-Like Growth Factor I Receptor and Urokinase Plasminogen Activator in Breast Cancer Is Associated with Poor Survival

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Osteoclastic Potential of Human CFU-GM: Biphasic Effect of GM-CSF

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Prostate carcinoma bone-stroma interaction and its biologic and therapeutic implications

2003 • 77 citations

T-Cells Mediate an Inhibitory Effect of Interleukin-4 on Osteoclastogenesis

2003 • 68 citations

Transfection of MDA-MB-231 human breast carcinoma cells with bone sialoprotein (BSP) stimulates migration and invasion in vitro and growth of primary and secondary tumors in nude mice

2004 • 48 citations

Thioredoxin-1 mediates osteoclast stimulation by reactive oxygen species

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Molecular Mechanisms of Bone Metastasis and Therapeutic Implications

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The Hsp90 chaperone as a promising drug target.

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Antitumour Effects of Bisphosphonates

2000 • 29 citations

Organ-selective chemoresistance in metastasis from human breast cancer cells: inhibition of apoptosis, genetic variability and microenvironment at the metastatic focus

2004 • 28 citations