Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Natural adjuvants: Endogenous activators of dendritic cells

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STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

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Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms.

2001 • 362 citations

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.

1995 • 351 citations

Genetic susceptibility to adverse drug reactions

2001 • 327 citations

Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis

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Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

1997 • 279 citations

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1998 • 269 citations

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

1998 • 238 citations

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

2000 • 227 citations

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals

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Sulfamethoxazole is metabolized to the hydroxylamine in humans

1992 • 172 citations

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

2000 • 155 citations

Contact allergy, irritancy and ‘danger’

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Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.

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Molecular mechanisms of CD8+ T cell–mediated delayed hypersensitivity: Implications for allergies, asthma, and autoimmunity

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T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

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Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

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Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

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Surface thiols of human lymphocytes and their changes after in vitro and in vivo activation

1996 • 98 citations

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

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Influence of reduced glutathione on the proliferative response of sulfamethoxazole‐specific and sulfamethoxazole‐metabolite‐specific human CD4+ T‐cells

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Comparison of the In Vitro Cytotoxicity of Hydroxylamine Metabolites of Sulfamethoxazole and Dapsone

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Chemical Activation of Innate and Specific Immunity in Contact Dermatitis

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Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

1996 • 66 citations

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.

1997 • 65 citations

Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8⁺cells by the hydroxylamine of sulfamethoxazole

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Plasma Cysteine Deficiency and Decreased Reduction of Nitrososulfamethoxazole with HIV Infection

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General and epidemiological aspects of allergic drug reactions.

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Toxicity of Sulfonamide-Reactive Metabolites in HIV-Infected, HTLV-Infected, and Noninfected Cells

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Contact Sensitivity in the Pig

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Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers*

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The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

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Analysis in the Rat of 4-Hydroxynonenal Metabolites Excreted in Bile: Evidence of Enterohepatic Circulation of These Byproducts of Lipid Peroxidation

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Contact sensitivity in the pig. II. Induction by intralymphatic infusion of DNP conjugated cells.

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ChemInform Abstract: Synthesis and Reactions of Nitroso Sulfamethoxazole with Biological Nucleophiles: Implications for Immune Mediated Toxicity.

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The reactivity of chloramphenicol reduction products with DNA bases

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