Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.

1995 • 351 citations

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

1997 • 279 citations

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1998 • 269 citations

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

1998 • 238 citations

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

1997 • 235 citations

Sulfamethoxazole is metabolized to the hydroxylamine in humans

1992 • 172 citations

Erythema multiforme: Clinical, histopathologic, and immunologic study

1984 • 153 citations

T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

1998 • 145 citations

Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides.

1988 • 143 citations

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

1999 • 131 citations

Clinical and Laboratory Markers of Hypersensitivity to Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia and AIDS

1993 • 126 citations

T Cell Recognition of Haptens, a Molecular View

1994 • 122 citations

Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophils from humans and dogs.

1990 • 105 citations

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

2006 • 98 citations

Recognition by Class II Alloreactive T Cells of Processed Determinants from Human Serum Proteins

1991 • 72 citations

Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones.

1999 • 71 citations

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

1996 • 66 citations

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.

1997 • 65 citations

Interaction of Sulfonamide Derivatives with the TCR of Sulfamethoxazole-Specific Human αβ+ T Cell Clones

1999 • 56 citations

Sulfonamide-induced reactions in desensitized patients with AIDS—The role of covalent protein haptenation by sulfamethoxazole☆☆☆★★★

1998 • 47 citations

Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection

1994 • 43 citations

Recognition of Local Anesthetics by αβ+ T Cells

1999 • 33 citations

Molecular Basis of Drug Recognition by Specific T–Cell Receptors

1999 • 30 citations

Cellular toxicity of sulfamethoxazole reactive metabolites—I

1991 • 26 citations

ChemInform Abstract: Synthesis and Reactions of Nitroso Sulfamethoxazole with Biological Nucleophiles: Implications for Immune Mediated Toxicity.

1996 • 15 citations

Pharmacokinetics of Sulfamethoxazole with its Hydroxy Metabolites and N4-Acetyl-, N1-Glucuronide Conjugates in Healthy Human Volunteers

1995 • 15 citations