Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

1975 • 1,175 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Platelet-derived growth factor: mechanism of action and possible in vivo function.

1990 • 491 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor

1989 • 216 citations

Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation

1991 • 196 citations

Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

1989 • 191 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

1990 • 169 citations

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.

1983 • 144 citations

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

1982 • 137 citations

Expression of Three Recombinant Homodimeric Isoforms of PDGF inSaccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities

1989 • 126 citations

Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.

1988 • 96 citations

Ligand-induced interaction between .alpha.- and .beta.-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation

1991 • 93 citations

A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet‐derived growth factor

1988 • 88 citations

Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor.

1988 • 68 citations

Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.

1991 • 45 citations