The Integrin α6β4 Functions in Carcinoma Cell Migration on Laminin-1 by Mediating the Formation and Stabilization of Actin-containing Motility Structures

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.

1991 • 574 citations

Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition.

1984 • 545 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.

1990 • 486 citations

Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes.

1990 • 462 citations

The nuclear matrix: Three-dimensional architecture and protein composition

1982 • 445 citations

Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

1995 • 440 citations

Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones

1996 • 403 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Expression of integrins and basement membrane components by wound keratinocytes.

1993 • 402 citations

Desmosomes and hemidesmosomes: structure and function of molecular components

1996 • 350 citations

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

1987 • 334 citations

The integrin alpha 6 beta 4 is a laminin receptor.

1992 • 299 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

Pioneer growth cone steering decisions mediated by single filopodial contacts in situ

1990 • 268 citations

Adhesion molecules in cancer: the role of integrins

1993 • 264 citations

N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells.

1979 • 261 citations

A function for the integrin alpha 6 beta 4 in the hemidesmosome.

1991 • 225 citations

Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo.

1993 • 224 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

The intracellular functions of alpha6beta4 integrin are regulated by EGF.

1996 • 188 citations

Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule.

1986 • 180 citations

Integrin dynamics on the tail region of migrating fibroblasts

1996 • 175 citations

Filopodia of spreading 3T3 cells. Do they have a substrate-exploring function?

1976 • 170 citations

Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing.

1991 • 168 citations

Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9.

1986 • 139 citations

Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin.

1995 • 137 citations

A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells.

1996 • 135 citations

The A9 Antigen Associated with Aggressive Human Squamous Carcinoma Is Structurally and Functionally Similar to the Newly Defined Integrin α6β4

1991 • 130 citations

Extension of filopodia by motor‐dependent actin assembly

1992 • 127 citations

Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins.

1990 • 127 citations

The integrin α6β4 and the biology of carcinoma

1996 • 123 citations

Changes in Integrin and E-Cadherin Expression in Neoplastic Versus Normal Thyroid Tissue

1996 • 105 citations

Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice.

1986 • 95 citations

Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium.

1997 • 95 citations

Actin based motility on retraction fibers in mitotic PtK2 cells

1992 • 87 citations

Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma. Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: implications for acquisition of the invading phenotype.

1996 • 87 citations

Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line

1993 • 86 citations

Demonstration of Type II Hemidesmosomes in a Mammary Gland Epithelial Cell Line, BMGE-H1

1994 • 83 citations

Cytostructural dynamics of spreading and translocating cells.

1982 • 80 citations

Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells

1993 • 74 citations

Integrin α 6β 4 mediates dynamic interactions with laminin

1994 • 61 citations

Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines.

1989 • 60 citations

Role of Integrins in Cell Adhesion and Polarity in Normal Keratinocytes and Human Skin Pathologies

1994 • 55 citations

The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.

1991 • 48 citations

The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin β4 subunit

1997 • 39 citations

Polarized Expression of HD1: Relationship with the Cytoskeleton in Cultured Human Colonic Carcinoma Cells

1997 • 37 citations

Expression of α6β4 integrin increases during malignant conversion of mouse epidermal keratinocytes: Association of β4 subunit to the cytokeratin fraction

1992 • 34 citations

Arcs: Curved microfilament bundles beneath the dorsal surface of the leading lamellae of moving chick embryo fibroblasts

1981 • 30 citations

Circular distribution of microfilaments in cells spreading in vitro

1978 • 14 citations

Metastatic Potential of Human Colorectal Cancer Cell Lines

1993 • 6 citations