Genetic variations in the interleukin-12/interleukin-23 receptor (β1) chain, and implications for IL-12 and IL-23 receptor structure and function

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2002 • 1,401 citations

[31] PHD: Predicting one-dimensional protein structure by profile-based neural networks

1996 • 1,291 citations

Interleukin-18 Regulates Both Th1 and Th2 Responses

2001 • 1,284 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Genetic Dissection of Immunity to Mycobacteria: The Human Model

2002 • 960 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation

2001 • 507 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

1998 • 427 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria

1998 • 327 citations

Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain.

1993 • 327 citations

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

1994 • 309 citations

Inherited Interleukin-12 Deficiency: IL12B Genotype and Clinical Phenotype of 13 Patients from Six Kindreds

2002 • 277 citations

Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae

2002 • 241 citations

IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells

2002 • 240 citations

Protein misfolding and degradation in genetic diseases

1999 • 223 citations

Detection of Active Tuberculosis Infection by T Cell Responses to Early‐Secreted Antigenic Target 6‐kDa Protein and Culture Filtrate Protein 10

2000 • 218 citations

Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfection

2000 • 178 citations

Interleukin‐12 Receptor β1 Deficiency in a Patient with Abdominal Tuberculosis

2001 • 168 citations

Differential Associations between the Cytoplasmic Regions of the Interleukin-12 Receptor Subunits β1 and β2 and JAK Kinases

1997 • 142 citations

Crystal structure of a cytokine-binding region of gp130

1998 • 125 citations

Interleukin-12: Basic Principles and Clinical Applications

1999 • 111 citations

Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain

1996 • 99 citations

Missense mutation of the interleukin-12 receptor β1 chain–encoding gene is associated with impaired immunity againstMycobacterium avium complex infection

2001 • 88 citations

Clinical and Genetic Heterogeneity of Inherited Autosomal Recessive Susceptibility to DisseminatedMycobacterium bovisBacille Calmette‐Guérin Infection

2002 • 85 citations

Severe Mycobacterium bovis BCG infections in a large series of novel IL–12 receptor β1 deficient patients and evidence for the existence of partial IL–12 receptor β1 deficiency

2002 • 81 citations

Altered Interleukin-12 Responsiveness in Th1 and Th2 Cells Is Associated With the Differential Activation of STAT5 and STAT1

1998 • 78 citations

Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1)

2000 • 76 citations

Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 130

2000 • 73 citations

Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1

2000 • 67 citations

Identification of a STAT4 Binding Site in the Interleukin-12 Receptor Required for Signaling

1999 • 65 citations

Analysis of the Multiple Interactions Between IL-12 and the High Affinity IL-12 Receptor Complex

1998 • 64 citations

MYCOBACTERIUM FORTUITUM-CHELONAE COMPLEX INFECTION IN A CHILD WITH COMPLETE INTERLEUKIN-12 RECEPTOR BETA 1 DEFICIENCY

2001 • 60 citations

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 • 53 citations

Four Contiguous Amino Acid Substitutions, Identified in Patients with Laron Syndrome, Differently Affect the Binding Affinity and Intracellular Trafficking of the Growth Hormone Receptor¹

1998 • 49 citations

A functional role of the membrane‐proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor

2002 • 44 citations

Direct Interaction of STAT4 with the IL-12 Receptor

1999 • 38 citations

Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation

2001 • 28 citations

A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction

2000 • 26 citations

Immune Deficiency Presenting as Mycobacterial Infection

2001 • 16 citations

Genomic organization of the human interleukin-12 receptor β 2 -chain gene

2000 • 13 citations