Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen

2001 • 11,901 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

2001 • 4,766 citations

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

1999 • 4,699 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Life with 6000 Genes

1996 • 4,125 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

Correlation between Protein and mRNA Abundance in Yeast

1999 • 3,800 citations

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

1987 • 3,628 citations

A Genomic Perspective on Protein Families

1997 • 3,531 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

1999 • 3,156 citations

Printing Proteins as Microarrays for High-Throughput Function Determination

2000 • 2,754 citations

Proteomics to study genes and genomes

2000 • 2,353 citations

High density synthetic oligonucleotide arrays

1999 • 2,256 citations

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle

1998 • 2,102 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Genome‐wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms

1998 • 1,498 citations

Linking genome and proteome by mass spectrometry: Large-scale identification of yeast proteins from two dimensional gels

1996 • 1,430 citations

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

2000 • 1,323 citations

MIPS: a database for genomes and protein sequences

2000 • 1,295 citations

A comparison of selected mRNA and protein abundances in human liver

1997 • 1,274 citations

Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues

1975 • 1,213 citations

[12] DNA arrays for analysis of gene expression

1999 • 1,053 citations

Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation

1998 • 957 citations

GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences

1999 • 901 citations

Membrane proteins and proteomics: Un amour impossible?

2000 • 850 citations

Analysis of yeast protein kinases using protein chips

2000 • 803 citations

Toward a protein–protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins

2000 • 799 citations

Upstream Open Reading Frames as Regulators of mRNA Translation

2000 • 728 citations

Transmembrane helices predicted at 95% accuracy

1995 • 669 citations

A Sampling of the Yeast Proteome

1999 • 629 citations

The dynamic range of protein expression: A challenge for proteomic research

2000 • 599 citations

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with β-branched residues at neighboring positions

2000 • 588 citations

Large-scale analysis of the yeast genome by transposon tagging and gene disruption

1999 • 536 citations

Global response of Saccharomyces cerevisiae to an alkylating agent

1999 • 426 citations

The relationship between protein structure and function: a comprehensive survey with application to the yeast genome

1999 • 402 citations

[17] Predicting optimal and suboptimal secondary structure for RNA

1990 • 383 citations

Analysis of large-scale gene expression data

2000 • 369 citations

Profiling Serine Hydrolase Activities in Complex Proteomes

2001 • 361 citations

Two-Dimensional Electrophoresis of Membrane Proteins Using Immobilized pH Gradients

2000 • 323 citations

Post-transcriptional gene regulatory mechanisms in eukaryotes: an overview

1998 • 302 citations

Computational methods for theidentification of differential and coordinated gene expression

1999 • 296 citations

The Yeast Proteome Database (YPD) and Caenorhabditis elegans Proteome Database (WormPD): comprehensive resources for the organization and comparison of model organism protein information

2000 • 290 citations

Structural and Genomic Correlates of Hyperthermostability

2000 • 271 citations

The Genomic Tree as Revealed from Whole Proteome Comparisons

1999 • 244 citations

Calculating nucleic acid secondary structure

2000 • 232 citations

Posttranscriptional Control of Gene Expression in Yeast

1998 • 225 citations

Direct Comparison of GeneChip and SAGE on the Quantitative Accuracy in Transcript Profiling Analysis

2000 • 211 citations

2D or not 2D

2001 • 202 citations

Two-Dimensional Gel Electrophoresis

1962 • 190 citations

A structural census of genomes: comparing bacterial, eukaryotic, and archaeal genomes in terms of protein structure

1997 • 184 citations

Distribution of Protein Folds in the Three Superkingdoms of Life

1999 • 183 citations

Do transmembrane protein superfolds exist?

1998 • 177 citations

Biosensor chip mass spectrometry: A chip-based proteomics approach

2000 • 171 citations

Proteomics: Capacityversus utility

2000 • 163 citations

Whole-genome Trees Based on the Occurrence of Folds and Orthologs: Implications for Comparing Genomes on Different Levels

2000 • 161 citations

Yeast Two-hybrid: So Many Interactions, (in) So Little Time…

1998 • 159 citations

Measuring gene expression by quantitative proteome analysis

2000 • 159 citations

Analysis of the yeast transcriptome with structural and functional categories: characterizing highly expressed proteins

2000 • 149 citations

A Bayesian system integrating expression data with sequence patterns for localizing proteins: comprehensive application to the yeast genome 1 1Edited by F. Cohen

2000 • 148 citations

Analysis of the microbial proteome

2000 • 142 citations

Microarray technology — enhanced versatility, persistent challenge

2000 • 142 citations

Large-Scale Gene Expression Data Analysis: A New Challenge to Computational Biologists

1999 • 142 citations

Proteome studies of Saccharomyces cerevisiae: Identification and characterization of abundant proteins

1997 • 140 citations

The nature of the universal ancestor and the evolution of the proteome

2000 • 137 citations

How representative are the known structures of the proteins in a complete genome? A comprehensive structural census

1998 • 136 citations

The stability of thermophilic proteins: a study based on comprehensive genome comparison

2000 • 132 citations

Patterns of protein-fold usage in eight microbial genomes: A comprehensive structural census

1998 • 120 citations

Proteome Profiling—Pitfalls and Progress

2000 • 111 citations

Better approaches to finding the needle in a haystack: Optimizing proteome analysis through automation

2000 • 109 citations

Proteomics: Theoretical and Experimental Considerations

1999 • 100 citations

The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability

1998 • 96 citations

The yeast two-hybrid system for studying protein—protein interactions

1995 • 91 citations

Comparing genomes in terms of protein structure: surveys of a finite parts list

1998 • 88 citations

The current excitement in bioinformatics—analysis of whole-genome expression data: how does it relate to protein structure and function?

2000 • 84 citations

Observing the living genome

1999 • 83 citations

Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability

1999 • 82 citations

Translational controls impinging on the 5′-untranslated region and initiation factor proteins

1997 • 82 citations

Proteome analysis of Saccharomyces cerevisiae: A methodological outline

1997 • 75 citations

Finding function through structural genomics

2000 • 69 citations

Genome-wide analysis relating expression level with protein subcellular localization

2000 • 68 citations

Alcohol dehydrogenase gene expression in potato following elicitor and stress treatment

1990 • 66 citations

RNA structure and the regulation of gene expression

1996 • 63 citations

Gel electrophoretic analysis of Zymomonas mobilis glycolytic and fermentative enzymes: identification of alcohol dehydrogenase II as a stress protein

1991 • 58 citations

Using bioinformatics in gene and drug discovery

2000 • 57 citations

Proteome of Salmonella typhimurium SL1344: identification of novel abundant cell envelope proteins and assignment to a two-dimensional reference map

1996 • 57 citations

Computational identification of cis-acting elements affecting post-transcriptional control of gene expression in Saccharomyces cerevisiae

2000 • 50 citations

Probing proteomes—seeing the whole picture?

2000 • 47 citations

Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!

2000 • 43 citations

The expression and anaerobic induction of alcohol dehydrogenase in cotton

1994 • 28 citations

Exploiting the complete yeast genome sequence

1996 • 27 citations

Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes

1992 • 25 citations

Unique identification of proteins from small genome organisms: Theoretical feasibility of high throughput proteome analysis

1997 • 21 citations

Genome-based structural biology

1999 • 18 citations

PROTEIN FOLDS IN THE WORM GENOME

1999 • 15 citations

The awesome power of yeast biochemical genomics

2000 • 13 citations

Spatial and free energy distribution patterns of amino acid residues in water soluble proteins

1994 • 9 citations

Encroaching genomics: adapting large-scale science to small academic laboratories

2000 • 4 citations

A possible in vivo mechanism of intermediate transfer by glycolytic enzyme complexes: Steady state fluorescence anisotropy analysis of an enzyme complex formation

1992 • 1 citations

Prokaryotes and lower eukaryotes

1992 • 1 citations

Deleted Work

1955 • 0 citations