New Concepts in the Pathophysiology of Inflammatory Bowel Disease

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2002 • 1,401 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

2001 • 1,096 citations

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

2004 • 1,052 citations

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

1996 • 961 citations

A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease

2000 • 724 citations

Bacterial flagellin is a dominant antigen in Crohn disease

2004 • 698 citations

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

2002 • 690 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Cytokines and autoimmunity

2002 • 663 citations

The Genetics of Inflammatory Bowel Disease

2007 • 572 citations

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene,mdr1a, Spontaneously Develop Colitis

1998 • 570 citations

Association of antibody responses to microbial antigens and complications of small bowel Crohn’s disease

2004 • 511 citations

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease

2000 • 495 citations

Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease

2000 • 450 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Inflammatory bowel disease: the role of environmental factors

2004 • 392 citations

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

2003 • 335 citations

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

2003 • 281 citations

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

2002 • 267 citations

Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

2001 • 247 citations

Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease

2000 • 242 citations

The Bacterial Flora in Inflammatory Bowel Disease: Current Insights in Pathogenesis and the Influence of Antibiotics and Probiotics

2001 • 240 citations

TH1-TH2: a Procrustean paradigm

2003 • 233 citations

Sero-Reactivity to Microbial Components in Crohn's Disease Is Associated with Disease Severity and Progression, but not NOD2/CARD15 Genotype

2004 • 230 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

Identification of a novel bacterial sequence associated with Crohn's disease

2000 • 216 citations

International Collaboration Provides Convincing Linkage Replication in Complex Disease through Analysis of a Large Pooled Data Set: Crohn Disease and Chromosome 16

2001 • 200 citations

Intestinal Epithelial Cells as a Source of Inflammatory Cytokines and Chemokines

2002 • 199 citations

Biology of IL‐21 and the IL‐21 receptor

2004 • 196 citations

Innate immunity and toll-like receptors: clinical implications of basic science research

2004 • 178 citations

NOD2 and Crohn’s Disease: Loss or Gain of Function?

2005 • 174 citations

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

2003 • 166 citations

Mouse models for the study of Crohn's disease

2003 • 165 citations

Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation

2005 • 161 citations

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

2003 • 154 citations

Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-γ, in mucosal inflammation

2004 • 148 citations

Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease

2002 • 148 citations

The genetics of inflammatory bowel disease

2001 • 143 citations

L-Selectin, α4β1, and α4β7 Integrins Participate in CD4+ T Cell Recruitment to Chronically Inflamed Small Intestine

2005 • 135 citations

Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases

2003 • 128 citations

Lamina Propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Proinflammatory Response Against an Intracellular Pathogen

2002 • 113 citations

Commentary: The role of the IL‐18 system and other members of the IL‐1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe?

2004 • 111 citations

In Vivo and In Vitro Roles of IL-21 in Inflammation

2004 • 108 citations

Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis

2002 • 107 citations

The Paneth cell and the innate immune response

2004 • 93 citations

Infliximab Efficacy in Pediatric Ulcerative Colitis

2005 • 88 citations

Infliximab in the treatment of steroid-dependent ulcerative colitis.

2005 • 82 citations

Cytokines in experimental colitis

1999 • 81 citations

IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis

2001 • 80 citations

Intestinal Epithelial Cell Regulation of Mucosal Inflammation

2004 • 75 citations

Update on the Genetics of Inflammatory Bowel Disease

2003 • 73 citations

High-Level Serum Antibodies to Bacterial Antigens Are Associated with Antibiotic-Induced Clinical Remission in Crohn's Disease: A Pilot Study

2004 • 53 citations

CD40L‐Induced IL‐12 Production is Further Enhanced by the Th2 Cytokines IL‐4 and IL‐13

2001 • 48 citations

Infliximab in the treatment of severe ulcerative colitis: a follow-up study.

2005 • 30 citations

Financial conflicts of interest

2005 • 24 citations

Deleted Work

1955 • 0 citations