Mouse models for the study of Crohn's disease

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

1990 • 2,321 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon

1989 • 1,681 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines

1998 • 1,038 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Oxazolone Colitis: A Murine Model of T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4

1998 • 523 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Tumor necrosis factor: Biology and therapeutic inhibitors

2000 • 358 citations

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

1998 • 273 citations

A comparative analysis of two models of colitis in rats

1992 • 265 citations

Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

2002 • 264 citations

Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

2001 • 247 citations

Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice

1994 • 204 citations

Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice

2001 • 201 citations

Severe colitis in mice with aberrant thymic selection

1995 • 186 citations

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

2003 • 154 citations

Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

1999 • 151 citations

Autoimmune Intestinal Pathology Induced by hsp60-Specific CD8 T Cells

1999 • 136 citations

Down-Regulation of Intestinal Lymphocyte Activation and Th1 Cytokine Production by Antibiotic Therapy in a Murine Model of Crohn’s Disease

2002 • 92 citations

Gi2? protein deficiency: A model for inflammatory bowel disease

1995 • 78 citations

XI. Novel mouse models to study pathogenic mechanisms of Crohn's disease

2000 • 60 citations