Messages and handshakes: cellular interactions in pulmonary fibrosis

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

1994 • 1,190 citations

Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

1979 • 958 citations

Bronchoalveolar lavage

2012 • 873 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Increased Production and Immunohistochemical Localization of Transforming Growth Factor-α in Idiopathic Pulmonary Fibrosis

1991 • 511 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

An Immunohistochemical Study of Architectural Remodeling and Connective Tissue Synthesis in Pulmonary Fibrosis

1989 • 469 citations

Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response

1992 • 459 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 • 420 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.

1994 • 353 citations

Cytokine production by mast cells and basophils

1991 • 344 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

1993 • 313 citations

Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis.

1988 • 287 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders.

1979 • 266 citations

Bronchoalveolar lavage in pulmonary fibrosis: comparison of cells obtained with lung biopsy and clinical features

1980 • 254 citations

Cellular and Molecular Basis of the Asbestos-related Diseases

1991 • 251 citations

Maintenance of Granuloma Formation in Pulmonary Sarcoidosis by T Lymphocytes within the Lung

1980 • 250 citations

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

1992 • 249 citations

Intraluminal fibrosis in interstitial lung disorders.

1986 • 249 citations

Structural Features of Interstitial Lung Disease in Systemic Sclerosis

1991 • 248 citations

Bronchoalveolar Lavage: Role in the Pathogenesis, Diagnosis, and Management of Interstitial Lung Disease

1985 • 240 citations

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

1987 • 239 citations

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

1983 • 217 citations

Structure of alveolar epithelial cells in patients with fibrotic lung disorders.

1982 • 199 citations

Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

1993 • 198 citations

Endothelial cell gene expression in response to injury

1993 • 194 citations

Role of growth factors in inflammation and repair

1989 • 189 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Asbestos Fibers and Silica Particles Stimulate Rat Alveolar Macrophages To Release Tumor Necrosis Factor: Autoregulatory Role of Leukotriene B₄

1989 • 173 citations

Collagen and Elastin in Human Pulmonary Emphysema

1993 • 169 citations

The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis.

1987 • 167 citations

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

1992 • 164 citations

The Effects of the Nude(nu/nu)Mutation on Bleomycin-induced Pulmonary Fibrosis

1983 • 145 citations

Pathogenesis of the granulomatous lung diseases.

1984 • 142 citations

Regulation of fibroblast proliferation and collagen synthesis by cytokines

1986 • 141 citations

Bleomycin-induced Pulmonary Fibrosis in Rats: Biochemical Demonstration of Increased Rate of Collagen Synthesis^1,2

1980 • 138 citations

Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4.

1990 • 132 citations

Macrophage-Derived Growth Factors

1992 • 131 citations

Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes.

1976 • 131 citations

Mast cell heterogeneity and hyperplasia in bleomycin-induced pulmonary fibrosis of rats.

1984 • 128 citations

Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellular responses to drug presence in the lung.

1979 • 125 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis.

1986 • 116 citations

Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury.

1993 • 115 citations

Contractile Cells in Normal and Fibrotic Lung

1990 • 107 citations

Pathogenesis of Pulmonary Fibrosis in Interstitial Lung Disease: Alveolar Macrophage PDGF(B) Gene Activation and Up-regulation by Interferon Gamma

1991 • 91 citations

Regulation of lung cell proliferation by polypeptide growth factors

1989 • 90 citations

Cellular and vascular manifestations of cell-mediated immunity

1986 • 88 citations

Presence of Platelet-derived Growth Factor in Normal and Fibrotic Lung Is Specifically Associated with Interstitial Macrophages, While Both Interstitial Macrophages and Alveolar Epithelial Cells Express the c-sis Proto-oncogene

1991 • 87 citations

The ultrastructure of human fibrosing alveolitis

1982 • 83 citations

Bacterial cell wall-induced hepatic granulomas. An in vivo model of T cell-dependent fibrosis.

1986 • 82 citations

Immunohistochemical localization of transforming growth factor-beta 1 in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer.

1993 • 82 citations

Juxtacrine Intercellular Signaling: Another Way to Do It

1993 • 80 citations

Similar action of platelet‐derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway

1985 • 79 citations

Alveolar macrophage stimulation of lung fibroblast growth in asbestos-induced pulmonary fibrosis.

1986 • 79 citations

Epidermal Growth Factor Transcription, Translation, and Signal Transduction by Rat Type II Pneumocytes in Culture

1992 • 77 citations

Expression of tumour necrosis factor‐α in cryptogenic fibrosing alveolitis

1993 • 76 citations

Kinetics of inflammatory and fibrotic pulmonary changes in a murine model of silicosis.

1985 • 76 citations

Remodeling of the Lung in Bleomycin-induced Pulmonary Fibrosis in the Rat: An Immunohistochemical Study of Laminin, Type IV Collagen, and Fibronectin

1990 • 76 citations

Interstitial Lung Disease

1988 • 75 citations

The Regulation of Lung Fibroblast Proliferation by Alveolar Macrophages in Experimental Silicosis^1–3

1984 • 71 citations

Epithelial-Mesenchymal Associations of Cells in Human Pulmonary Fibrosis and in BHT-Oxygen-Induced Fibrosis in Mice

1981 • 68 citations

Susceptibility to experimental interstitial lung disease is modified by immune- and non-immune-related genes.

1987 • 63 citations

Collagen Cross-linking in Adult Patients with Acute and Chronic Fibrotic Lung Disease: Molecular Markers for Fibrotic Collagen

1990 • 62 citations

Usual interstitial pneumonitis is a T-cell alveolitis

1986 • 61 citations

Interferon-gamma and Synthesis of Surfactant Components by Cultured Human Fetal Lung

1990 • 60 citations

Differential effects of mineral dusts on the in vitro activation of alveolar macrophage eicosanoid and cytokine release

1990 • 59 citations

Quantitative immunohistologic assessment of lymphocyte populations in the pulmonary inflammatory response to intratracheal silica.

1989 • 58 citations

Comparison of alveolar and interstitial macrophages in fibroblast stimulation after silica and long or short asbestos.

1991 • 57 citations

Interstitial pulmonary macrophages produce platelet-derived growth factor that stimulates rat lung fibroblast proliferation in vitro

1992 • 56 citations

Bleomycin-Induced Pulmonary Fibrosis in Genetically Mast Cell-Deficient WBB6F<sub>1</sub>-W/W<sup>v</sup> Mice and Mechanism of the Suppressive Effect of Tranilast, an Antiallergic Drug Inhibiting Mediator Release from Mast Cells, on Fibrosis

1991 • 54 citations

Enhanced macrophage-fibroblast interactions in the pulmonary interstitium increases fibrosis after silica injection to monocyte-depleted mice.

1989 • 53 citations

Cytokine-Induced Expression of Transforming Growth Factor-α and the Epidermal Growth Factor Receptor in Neonatal Skin Explants

1992 • 50 citations

Mast Cells and Biogenic Amines in Radiation-induced Pulmonary Fibrosis

1993 • 50 citations

Fibroblast Proliferation Induced by Silica-exposed Human Alveolar Macrophages

1988 • 49 citations

Cell Proliferation during the Process of Bleomycin‐induced Pulmonary Fibrosis in Rats

1990 • 49 citations

Mechanisms of Drug-Induced Pulmonary Disease

1988 • 48 citations

Apposition of fibroblasts to mast cells and lymphocytes in normal human lung and in cryptogenic fibrosing alveolitis. Ultrastructure and cell perimeter measurements

1992 • 47 citations

Injury to type-2 pneumocytes in rats exposed to cigarette smoke

1981 • 46 citations

Lung Fibroblasts Produce Growth Stimulatory Activity for Bronchial Epithelial Cells

1990 • 45 citations

Mast Cells Are Essential for the Full Development of Silica-induced Pulmonary Inflammation: A Study with Mast Cell-deficient Mice

1993 • 44 citations

Lymphokine regulation of macrophage-derived growth factor secretion following pulmonary injury.

1985 • 43 citations

T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda)

1978 • 43 citations

Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts

1989 • 42 citations

Extracellular Matrix Components in Bronchoalveolar Lavage Fluid in Sarcoidosis and Their Relationship to Signs of Alveolitis

1990 • 41 citations

Clonal analysis of murine graft-vs-host disease. II. Leukokines that stimulate fibroblast proliferation and collagen synthesis in graft-vs. host disease.

1986 • 40 citations

Inhalation of chrysotile asbestos induces rapid cellular proliferation in small pulmonary vessels of mice and rats.

1990 • 39 citations

Role for T lymphocytes in silica-induced pulmonary inflammation.

1989 • 39 citations

Reduced yield of pulmonary surfactant: Patterns of response following administration of chemicals to rats by inhalation

1980 • 37 citations

Immunogenetic Analysis of Silicosis in Japan

1993 • 36 citations

Modulation of fibroblast activity by normal and silica‐exposed alveolar macrophages

1986 • 36 citations

Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis.

1991 • 35 citations

Lymphocytes and arachidonic acid metabolism.

1988 • 35 citations

Pathogenetic Significance of Reactive Oxygen Species in Diffuse Fibrosing Alveolitis

1991 • 35 citations

Lung and Blood Lymphocyte Subsets in Asbestosis and in Mixed Dust Pneumoconiosis

1987 • 35 citations

Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair.

1993 • 34 citations

Comparison of Lung Alveolar and Tissue Cells in Silica-induced Inflammation

1991 • 34 citations

Interleukin 1 Production and Accessory Cell Function of Rat Alveolar Macrophages Exposed to Mineral Dust Particles

1987 • 34 citations

Role of lymphocytes in silicosis: regulation of secretion of macrophage-derived mitogenic activity for fibroblasts.

1992 • 33 citations

Cellular sensitivity to collagen in bleomycin-treated rats.

1982 • 33 citations

Mast Cells Modulate Acute Ozone-induced Inflammation of the Murine Lung

1993 • 33 citations

Primary culture of adult mouse lung fibroblasts in serum-free medium: Responses to growth factors

1991 • 31 citations

Pulmonary inflammation and fibrosis following subacute inhalational exposure to silica: determinants of progression

1993 • 31 citations

Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor

1989 • 30 citations

Quartz Exposure, Retention, and Early Silicosis in Sheep

1989 • 30 citations

Activation of Lymphocytes in the Pulmonary Inflammatory Response to Silica

1990 • 25 citations

Correlation of biochemical and morphological changes induced by chemical injury to the lung

1979 • 25 citations

Pulmonary Interstitial Fibrosis Induced in Hapten-Immune Hamsters

1987 • 24 citations

Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice

1989 • 23 citations

The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury

1990 • 23 citations

Transgenic mice in the study of cytokine function.

1993 • 22 citations

Pulmonary responses to atmospheric pollutants. I: an ultrastructural study of fibrosing alveolitis evoked by petrol vapour

1979 • 21 citations

The pathogenesis of the Hamman-Rich syndrome; a review from the standpoint of possible allergic etiology.

1958 • 20 citations

Serum glucocorticoids have persistent and controlling effects on insulinlike growth factor i action under serum-free assay conditions in cultured human fibroblasts

1989 • 20 citations

Lymphocytes and Arachidonic Acid Metabolism

1988 • 20 citations

Chrysotile Asbestos Inhalation Induces Tritiated Thymidine Incorporation by Epithelial Cells of Distal Bronchioles

1989 • 20 citations

Lung fibroblasts from animals breathing 100% oxygen produce growth factors for alveolar type II cells

1990 • 20 citations

Pulmonary reaction to long and short asbestos fibers is independent of fibroblast growth factor production by alveolar macrophages.

1990 • 20 citations

Pulmonary responses to bleomycin-induced injury: an immunomorphologic and electron microscopic study

1985 • 19 citations

Abnormal alveolar epithelial repair associated with failure of resolution in experimental streptococcal pneumonia

1989 • 17 citations

[5] Identification and assay of platelet-derived growth factor-binding proteins

1987 • 17 citations

Dog Mastocytoma Cells Secrete a Growth Factor for Fibroblasts

1992 • 17 citations

Inorganic Particles Induce Secretion of a Macrophage Homologue of Platelet-Derived Growth Factor in a Density- and Time-Dependent Manner in Vitro

1991 • 16 citations

Mitogenic activity for fibroblasts induced by silica and titanium dioxide particles in vitro and in vivo.

1992 • 16 citations

Environmental pathology : an evolving field

1982 • 14 citations

Atypical mast cell degranulation and focal hydropic degeneration of venular endothelium in diffuse fibrosing alveolitis

1979 • 13 citations

Secretion of Epidermal Growth Factor-Like Molecular Species by Lung Parenchymal Macrophages: Induction by Interferon-γ

1993 • 10 citations

Evaluation of the expression of IFN-γ in lymphocytes using a monoclonal antibody and flow cytometry

1988 • 9 citations

Regulation of lung fibroblast proliferation and collagen synthesis by alveolar macrophages in experimental silicosis. I: Effect of macrophage conditioned medium from silica instilled rats.

1986 • 9 citations

Partial characterization of a fibroblast-stimulating factor produced by cloned murine T lymphocytes.

1988 • 9 citations

Contact formation and transfer of mannose BSA gold from macrophages to cocultured fibroblasts

1991 • 8 citations

Recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) induces human macrophage production of transforming growth factor-alpha.

1991 • 6 citations

Atypical differentiation of bronchiolar epithelial cells following experimental pneumonia

1990 • 2 citations

Lymphokine-Induced Phenotypic Changes in Cells of a Type 2 Pneumocyte-Related Strain: Characterization of Activity in Mitogen-Stimulated Spleen Cell Supernatants

1987 • 1 citations