The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

1993 • 632 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

1992 • 619 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

1995 • 537 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

The pre-mRNA binding K protein contains a novel evolutionary conserved motif

1993 • 526 citations

A Y chromosome gene family with RNA-binding protein homology: Candidates for the azoospermia factor AZF controlling human spermatogenesis

1993 • 515 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.

1994 • 481 citations

Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

1994 • 442 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

1988 • 399 citations

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

1994 • 321 citations

In Vivo and In Vitro Arginine Methylation of RNA-Binding Proteins

1995 • 302 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

1989 • 236 citations

Cellular Nucleic Acid Binding Protein Regulates the CT Element of the Human c- myc Protooncogene

1995 • 234 citations

An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis.

1994 • 234 citations

A Pre-mRNA-Binding Protein Accompanies the RNA from the Gene through the Nuclear Pores and into Polysomes

1996 • 220 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

The glycine-rich domain of nucleolin has an unusual supersecondary structure responsible for its RNA-helix-destabilizing properties.

1992 • 194 citations

Interaction of the RNA-binding domain of the hnRNP C proteins with RNA.

1992 • 186 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

Transcription-Dependent and Transcription-Independent Nuclear Transport of hnRNP Proteins

1991 • 184 citations

Phenylalanines that are conserved among several RNA-binding proteins form part of a nucleic acid-binding pocket in the A1 heterogeneous nuclear ribonucleoprotein.

1988 • 180 citations

hnRNP A1 Selectively Interacts Through its Gly-rich Domain with Different RNA-binding Proteins

1996 • 179 citations

Cell Type-Specific Expression of hnRNP Proteins

1995 • 177 citations

Nucleo-cytoplasmic distribution of human hnrnp proteins: a search for the targeting domains in hnrnp a1

1995 • 158 citations

The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins.

1994 • 155 citations

HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression.

1995 • 149 citations

RNA annealing activities in HeLa nuclei.

1994 • 148 citations

The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization

1994 • 147 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

hnRNP G: sequence and characterization of a glycosylated RNA-binding protein

1993 • 141 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

Characterization of the major hnRNP proteins from Drosophila melanogaster.

1992 • 130 citations

Proton, carbon-13, and nitrogen-15 NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins

1992 • 125 citations

Purification and Characterization of a Protein That Permits Early Detection of Lung Cancer

1996 • 118 citations

Studies of the strand-annealing activity of mammalian hnRNP complex protein A1

1990 • 114 citations

Association of individual hnRNP proteins and snRNPs with nascent transcripts.

1993 • 113 citations

Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry.

1995 • 111 citations

The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins

1993 • 103 citations

The core proteins of 35 S hnRNP complexes

1985 • 101 citations

Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing.

1992 • 98 citations

Identification, Molecular Cloning, Expression and Chromosome Mapping of a Family of Transformation Upregulated hnRNP-K Proteins Derived by Alternative Splicing

1994 • 91 citations

Phosphorylation of human hnRNP protein A1 abrogatesin vitrostrand annealing activity

1993 • 91 citations

Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

1990 • 86 citations

Identification of Heterogeneous Ribonucleoprotein A1 as a Novel Substrate for Protein Kinase C ζ

1995 • 85 citations

Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae.

1994 • 82 citations

Retroviral Insertions Downstream of the Heterogeneous Nuclear Ribonucleoprotein Al Gene in Erythroleukemia Cells: Evidence that Al Is Not Essential for Cell Growth

1992 • 79 citations

New insights into the auxiliary domains of eukaryotic RNA binding proteins

1994 • 78 citations

The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.

1994 • 72 citations

Cell Cycle-Regulated Phosphorylation of the Pre-mRNA-Binding (Heterogeneous Nuclear Ribonucleoprotein) C Protein

1993 • 63 citations

Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides homologous to intron/exon acceptor sites

1990 • 61 citations

Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1

1994 • 59 citations

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.

1992 • 56 citations

Human hnRNP Protein A1 Gene Expression

1993 • 54 citations

Crosslinking of hnRNP protiens to pre-mRNA requires U1 and U2 snRNPs

1990 • 54 citations

Mammalian heterogeneous nuclear ribonucleoprotein A1. Nucleic acid binding properties of the COOH-terminal domain.

1990 • 53 citations

Structural interaction between the nuclear pore complex and a specific translocating RNP particle.

1995 • 53 citations

Regulation of in vitro nucleic acid strand annealing activity of heterogeneous nuclear ribonucleoprotein protein A1 by reversible phosphorylation

1994 • 49 citations

Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly

1992 • 49 citations

Cell cycle-regulated phosphorylation of the pre-mRNA-binding (heterogeneous nuclear ribonucleoprotein) C proteins.

1993 • 44 citations

Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth.

1992 • 40 citations

Large‐scale purification of hnRNP proteins from HeLa cells by affinity chromatography on ssDNA‐cellulose

1987 • 30 citations

Changes in heterogeneous nuclear RNP core polypeptide complements during the cell cycle.

1987 • 30 citations

Functions of Nuclear Pre-mRNA/mRNA Binding Proteins

1995 • 30 citations

Disruption of Base-paired U4·U6 Small Nuclear RNAs Induced by Mammalian Heterogeneous Nuclear Ribonucleoprotein C Protein

1995 • 17 citations

Solar systems in the making

1990 • 12 citations