Deregulation of the Egfr/Ras Signaling Pathway Induces Age-related Brain Degeneration in theDrosophilaMutantvap

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

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Drosophila — A Practical Approach

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Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Drosophila: a laboratory manual

1990 • 1,081 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes.

1996 • 564 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development

1991 • 491 citations

The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling

1998 • 477 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

Sprouty, an Intracellular Inhibitor of Ras Signaling

1999 • 462 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

The Ras branch of small Gtpases: Ras family members don’t fall far from the tree

2000 • 408 citations

P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.

1989 • 401 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression

1998 • 378 citations

Caspase-independent programmed cell death with necrotic morphology

1999 • 378 citations

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

1995 • 368 citations

The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages

1988 • 351 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1998 • 295 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

1999 • 244 citations

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

1997 • 234 citations

The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm

1996 • 232 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

TheSwiss CheeseMutant Causes Glial Hyperwrapping and Brain Degeneration inDrosophila

1997 • 209 citations

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport

1999 • 204 citations

The neurotrophic action and signalling of epidermal growth factor

1997 • 198 citations

Isolation of Anatomical Brain Mutants of Drosophila by Histological Means

1979 • 193 citations

Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation

1998 • 170 citations

Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

1989 • 163 citations

Cell death mechanisms in neurodegeneration

2001 • 160 citations

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

1999 • 150 citations

Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm).

1996 • 149 citations

The torso receptor tyrosine kinase can activate raf in a ras-independent pathway

1995 • 111 citations

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer

2000 • 107 citations

Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts

1986 • 106 citations

Opposing Actions of CSW and RasGAP Modulate the Strength of Torso RTK Signaling in the Drosophila Terminal Pathway

1998 • 92 citations

The fine structure of neuroglia in the lamina ganglionaris of the housefly,Musca domestica L.

1983 • 85 citations

Aberrant Ras Regulation and Reduced p190 Tyrosine Phosphorylation in Cells Lacking p120-Gap

1997 • 80 citations

A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system

1998 • 77 citations

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

1995 • 68 citations

TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock

1999 • 56 citations

Tissue Localization of Drosophila melanogaster ras Transcripts during Development

1986 • 54 citations

Glial membrane specializations and the compartmentalization of the lamina ganglionaris of the housefly compound eye

1983 • 52 citations

Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway

1998 • 47 citations

Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs

1998 • 42 citations

Tissue localization of Drosophila melanogaster ras transcripts during development.

1986 • 37 citations

Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

1999 • 34 citations

Control of Growth and Differentiation by Drosophila RasGAP, a Homolog of p120 Ras–GTPase-Activating Protein

1999 • 29 citations

mip causes hyperinnervation of a retinotopic map in drosophila by excessive recruitment of R7 photoreceptor cells

1992 • 29 citations

Proteolytic cleavage of Ras GTPase-activating protein during apoptosis

1998 • 21 citations