Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

1995 • 368 citations

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

1995 • 342 citations

The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

1996 • 171 citations

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

1988 • 160 citations

The GTPase Rho has a critical regulatory role in thymus development

1997 • 135 citations

Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression.

1998 • 120 citations

Ras-GTPase Activating Protein (GAP): A Putative Effector for Ras

1997 • 105 citations

GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion

1992 • 101 citations

p120 GAP Modulates Ras Activation of Jun Kinases and Transformation

1997 • 97 citations

Toxin-Induced Activation of Rho GTP-Binding Protein Increases Bcl-2 Expression and Influences Mitochondrial Homeostasis

1998 • 92 citations

Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4.

1996 • 79 citations

Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras.

1998 • 66 citations

Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis

1997 • 65 citations

Ras-GAP Controls Rho-Mediated Cytoskeletal Reorganization through Its SH3 Domain

1998 • 64 citations

Implication of GAP in Ras-dependent transactivation of a polyoma enhancer sequence

1992 • 23 citations

Antibodies to Synthetic Peptide from the Residue 33 to 42 Domain of c-Ha-ras p21 Block Reconstitution of the Protein with Different Effectors

1989 • 23 citations

Mechanisms of resistance to therapy and tumor cell survival

1995 • 17 citations

Non–Neutralizing Monoclonal Antibodies Against RAS GTPase–Activating Protein: Production, Characterization and Use in an Enzyme Immunometric Assay

1992 • 15 citations

Alterations of G-Protein Coupling Function in Phosphoinositide Signaling Pathways of Cells Transformed by ras and Other Membrane-Associated and Cytoplasmic Oncogenes

1990 • 15 citations

Antibodies to synthetic peptide from the residue 33 to 42 domain of c-Ha-ras p21 block reconstitution of the protein with different effectors.

1989 • 11 citations