Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture

1995 • 847 citations

Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase

1990 • 841 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

1993 • 653 citations

Regulators of cell death

1995 • 647 citations

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

1994 • 630 citations

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.

1991 • 558 citations

Cell death during differentiation of the retina in the mouse

1984 • 531 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Differential effect of the rd mutation on rods and cones in the mouse retina.

1978 • 493 citations

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.

1983 • 412 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa.

1995 • 286 citations

The loss of ganglion cells in the developing retina of the rat

1982 • 266 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

Protection of Retinal Ganglion Cells from Natural and Axotomy-Induced Cell Death in Neonatal Transgenic Mice Overexpressing bcl-2

1996 • 239 citations

Adenovirus-Mediated Gene Transfer of Ciliary Neurotrophic Factor Can Prevent Photoreceptor Degeneration in the Retinal Degeneration (rd) Mouse

1997 • 222 citations

Bax promotes neuronal cell death and is downregulated during the development of the nervous system

1997 • 217 citations

bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations.

1996 • 212 citations

Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice

1996 • 200 citations

Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction.

1994 • 195 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit.

1992 • 164 citations

Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina

1995 • 162 citations

Different forms of the neurotrophin receptor TrkB mRNA predominate in rat retina and optic nerve

1993 • 151 citations

Long‐term Survival of Retina Optic Nerve Section in Adult Ganglion Cells Following bcl‐2 Transgenic Mice

1996 • 147 citations

Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. A quantitative analysis in the cat

1984 • 126 citations

Expression of the proto-oncogene, trk, receptors in the developing rat retina

1995 • 116 citations

The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2

1996 • 90 citations

Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration.

1996 • 80 citations

TrkA, TrkB and p75 mRNA expression is developmentally regulated in the rat retina

1995 • 75 citations

NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats

1994 • 55 citations

Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.

1996 • 55 citations

Susceptibility of Cerebellar Granule Neurons Derived from Bcl‐2‐Deficient and Transgenic Mice to Cell Death

1997 • 52 citations

The effect of intraocular tetrodotoxin on the postnatal reduction in the numbers of optic nerve axons in the rat

1986 • 39 citations

Receptive-field properties of displaced starburst amacrine cells change following axotomy-induced degeneration of ganglion cells

1995 • 20 citations

NMDA Receptor Blockade Alters the Topography of Naturally Occurring Ganglion Cell Death in the Rat Retina

1993 • 16 citations