CD39/Adenosine Pathway Is Involved in AIDS Progression

Principal components analysis corrects for stratification in genome-wide association studies

2006 • 9,771 citations

How regulatory T cells work

2008 • 3,048 citations

A new multipoint method for genome-wide association studies by imputation of genotypes

2007 • 2,593 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

2001 • 1,261 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation

2006 • 983 citations

A genome-wide association study of global gene expression

2007 • 954 citations

The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance

2006 • 880 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A_2AR<scp>eceptors</scp>

2004 • 672 citations

Pathophysiology and Therapeutic Potential of Purinergic Signaling

2006 • 597 citations

An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection

2004 • 558 citations

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

1997 • 479 citations

The Inflammasome: First Line of the Immune Response to Cell Stress

2006 • 469 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

2004 • 444 citations

T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5′-Adenosine Monophosphate to Adenosine

2006 • 440 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

2004 • 387 citations

Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells

2004 • 333 citations

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

2004 • 322 citations

New Class I and II HLA Alleles Strongly Associated with Opposite Patterns of Progression to AIDS

1999 • 297 citations

CD39 and control of cellular immune responses

2007 • 281 citations

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

2009 • 263 citations

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?

2005 • 263 citations

Immune Suppression in the Tumor Microenvironment

2006 • 259 citations

The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization.

1994 • 256 citations

Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection

2006 • 241 citations

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

2008 • 233 citations

Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response.

1996 • 209 citations

THE GENETICAL INTERPRETATION OF STATISTICS OF THE THIRD DEGREE IN THE STUDY OF QUANTITATIVE INHERITANCE

1932 • 191 citations

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

2009 • 190 citations

High Sensitivity of CD4+CD25+ Regulatory T Cells to Extracellular Metabolites Nicotinamide Adenine Dinucleotide and ATP: A Role for P2X7 Receptors

2005 • 184 citations

High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock

2000 • 182 citations

Suppression of HIV-specific T cell activity by lymph node CD25⁺regulatory T cells from HIV-infected individuals

2007 • 181 citations

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3⁺T Regulatory Cells Correlates with Progressive Disease

2010 • 169 citations

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

2009 • 166 citations

WGAViewer: Software for genomic annotation of whole genome association studies: Figure 1.

2008 • 163 citations

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

2009 • 150 citations

Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo

2005 • 147 citations

CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73.

1995 • 144 citations

The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases

2003 • 143 citations

Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03)

2009 • 104 citations

Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

2008 • 87 citations

Expansion of FOXP3+ CD8 T Cells with Suppressive Potential in Colorectal Mucosa Following a Pathogenic Simian Immunodeficiency Virus Infection Correlates with Diminished Antiviral T Cell Response and Viral Control

2010 • 78 citations

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1996 • 76 citations

Multistage Genomewide Association Study Identifies a Locus at 1q41 Associated with Rate of HIV‐1 Disease Progression to Clinical AIDS

2010 • 71 citations

Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets

2009 • 56 citations

HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection

2008 • 54 citations

HIV infection is associated with increased NTPDase activity that correlates with CD39-positive lymphocytes

2005 • 53 citations

Dominant Effects of CCR2-CCR5 Haplotypes in HIV-1 Disease Progression

2004 • 39 citations