High Sensitivity of CD4+CD25+ Regulatory T Cells to Extracellular Metabolites Nicotinamide Adenine Dinucleotide and ATP: A Role for P2X7 Receptors

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

Physiological concentrations of purines and pyrimidines

1994 • 1,722 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

2001 • 828 citations

Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38

1993 • 735 citations

Nucleotide receptors: an emerging family of regulatory molecules in blood cells

2001 • 724 citations

Pharmacology of Cloned P2X Receptors

2000 • 701 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

2002 • 492 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

2004 • 443 citations

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

1987 • 407 citations

Mechanisms for the induction of autoimmunity by infectious agents

2001 • 354 citations

Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X₇ receptor

1999 • 345 citations

Mechanisms for the induction of autoimmunity by infectious agents

2001 • 340 citations

NAD-Induced T Cell Death

2003 • 312 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

ATP-mediated cytotoxicity in microglial cells

1997 • 280 citations

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death

1999 • 276 citations

ATP-stimulated Release of Interleukin (IL)-1β and IL-18 Requires Priming by Lipopolysaccharide and Is Independent of Caspase-1 Cleavage

2001 • 259 citations

Isoquinolines as Antagonists of the P2X₇Nucleotide Receptor: High Selectivity for the Human versus Rat Receptor Homologues

1998 • 218 citations

The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes

1997 • 195 citations

Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor

2002 • 194 citations

An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytes

1996 • 188 citations

ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X₇ Receptor Channels

2002 • 159 citations

Mouse Dendritic Cells Express the P2X7 Purinergic Receptor: Characterization and Possible Participation in Antigen Presentation

1999 • 153 citations

Maitotoxin and P2Z/P2X₇purinergic receptor stimulation activate a common cytolytic pore

1999 • 139 citations

Extracellular ATP induces a large nonselective conductance in macrophage plasma membranes.

1988 • 134 citations

P2Z adenosine triphosphate receptor activity in cultured human monocyte- derived macrophages

1994 • 133 citations

Lipopolysaccharide induces expression of tumour necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram

1997 • 112 citations

Regulation of cytotoxic T cells by ecto-nicotinamide adenine dinucleotide (NAD) correlates with cell surface GPI-anchored/arginine ADP-ribosyltransferase.

1994 • 92 citations

[19] Tissue NAD as a biochemical measure of niacin status in humans

1997 • 92 citations

Premature Stop Codons Inactivate the RT6 Genes of the Human and Chimpanzee Species

1994 • 79 citations

Apparent species differences in the kinetic properties of P2X₇ receptors

2000 • 73 citations

Identification of Autonomously Replicating Sequence (ARS) Elements in Eukaryotic Cells

1997 • 64 citations

Rapid Induction of Naive T Cell Apoptosis by Ecto-Nicotinamide Adenine Dinucleotide: Requirement for Mono(ADP-Ribosyl)Transferase 2 and a Downstream Effector

2001 • 64 citations

Purification and Characterization of NAD Glycohydrolase from Rabbit Erythrocytes

1993 • 62 citations

P2X7 Receptor-Dependent and -Independent T Cell Death Is Induced by Nicotinamide Adenine Dinucleotide

2005 • 59 citations

Release of a glycosylphosphatidylinositol-anchored ADP-ribosyltransferase from cytotoxic T cells upon activation.

1996 • 48 citations

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine

2003 • 46 citations

Extracellular Nicotinamide Adenine Dinucleotide Induces T Cell Apoptosis In Vivo and In Vitro

2001 • 44 citations

Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X7 Receptor

2004 • 37 citations

P2Z adenosine triphosphate receptor activity in cultured human monocyte- derived macrophages

1994 • 15 citations

Metabolic fate of extracellular NAD in human skin fibroblasts

2000 • 13 citations