Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH

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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Principles of biochemistry

1994 • 930 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification

1995 • 243 citations

Interleukin-7: physiological roles and mechanisms of action

1999 • 243 citations

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

1998 • 186 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.

1996 • 153 citations

[17] Isolation of integral membrane proteins by phase partitioning with triton X-114

1994 • 152 citations

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

1998 • 128 citations

Intracellular acidification induces apoptosis by stimulating ICE-like protease activity

1997 • 118 citations

Effects of Na+/H+ antiport and intracellular pH in the regulation of HL-60 cell apoptosis

1995 • 60 citations

The Action of Bax and Bcl-2 on T Cell Selection

1998 • 59 citations

Measurement of intracellular pH in cultured cells by flow cytometry with BCECF-AM

1996 • 58 citations

Activation of the Na(+)/H(+) antiporter, Na+/HCO3(-)/CO3(2-) cotransporter, or Cl(-)/HCO3(-) exchanger in spontaneous thymocyte apoptosis.

1996 • 49 citations

pH homeostasis in promyelocytic leukemic HL60 cells.

1988 • 35 citations

Identification of Functional Domains and Critical Residues in the Adenosinetriphosphatase Inhibitor Protein of Mitochondrial F₀F₁ ATP Synthase

1996 • 30 citations

Partitioning of Proteins in Triton X-114

2003 • 19 citations

Increase of intracellular pH in p53-dependent apoptosis of thymocytes induced by gamma radiation.

1998 • 18 citations

Increase of Intracellular pH in p53-Dependent Apoptosis of Thymocytes Induced by Gamma Radiation

1998 • 15 citations

The Role of the Common Gamma Chain of the IL-2, IL-4, IL-7 and IL-15 Receptors in Development of Lymphocytes. Constitutive Expression of Bcl-2 does not Rescue the Developmental Defects in Gamma Common-Deficient Mice

1997 • 13 citations