Analysis of Mechanisms That Determine Dominant Negative Estrogen Receptor Effectiveness

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

1991 • 262 citations

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

1992 • 251 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists.

1995 • 230 citations

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen.

1993 • 215 citations

Identification of a Dominant Negative Form of the Human Estrogen Receptor

1991 • 211 citations

Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators.

1993 • 197 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance

1993 • 149 citations

Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome.

1994 • 133 citations

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells

1991 • 128 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

1993 • 118 citations

A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells

1989 • 101 citations

Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor. Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands

1991 • 100 citations

Thyroid Hormone Receptor Mutations that Interfere with Transcriptional Activation also Interfere with Receptor Interaction with a Nuclear Protein

1991 • 93 citations

Dominant negative regulation of trans-activation by the rat androgen receptor: roles of the N-terminal domain and heterodimer formation.

1993 • 88 citations

The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene.

1992 • 75 citations

Hormone binding and transcription activation by estrogen receptors: Analyses using mammalian and yeast systems

1993 • 75 citations

Nuclear Hormone Receptors

2011 • 51 citations

Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.

1992 • 43 citations

Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.

1993 • 41 citations

Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors.

1995 • 41 citations

Estrogen receptor mutants which do not bind 17 beta-estradiol dimerize and bind to the estrogen response element in vivo.

1995 • 40 citations

The dominant negative effect of thyroid hormone receptor splicing variant alpha 2 does not require binding to a thyroid response element.

1995 • 39 citations

Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA.

1994 • 38 citations

Two functional forms of the Xenopus laevis estrogen receptor translated from a single mRNA species.

1994 • 24 citations

Mechanistic analysis of estrogen receptor action using dominant negative mutants

1995 • 1 citations