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Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes

Data up to Jan 2025

Published2006
Citations33
References36

Total Citations Per Year

Abstract

References (36)

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

Impact of Drug Transporter Studies on Drug Discovery and Development

2003 • 493 citations

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

1994 • 260 citations

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

1993 • 225 citations

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

1999 • 223 citations

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

1999 • 219 citations

Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals.

1994 • 166 citations

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

2004 • 150 citations

Cultured Rat Hepatocytes

1996 • 136 citations

Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.

1999 • 132 citations

Evaluation of Hepatotoxic Potential of Drugs by Inhibition of Bile-Acid Transport in Cultured Primary Human Hepatocytes and Intact Rats

2003 • 129 citations

P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION

2005 • 114 citations

CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam

2003 • 103 citations

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2

2004 • 98 citations

P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.

2001 • 93 citations

THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING

2004 • 93 citations

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

2002 • 83 citations

The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies

1995 • 82 citations

Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

1991 • 72 citations

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

1999 • 66 citations

Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin.

1997 • 57 citations

Bioavailability of terfenadine in man

1981 • 57 citations

EFFECT OF DEXAMETHASONE TREATMENT ON THE EXPRESSION AND FUNCTION OF TRANSPORT PROTEINS IN SANDWICH-CULTURED RAT HEPATOCYTES

2004 • 56 citations

Primary Hepatocyte Cultures as an in Vitro Experimental Model for the Evaluation of Pharmacokinetic Drug–Drug Interactions

1997 • 56 citations

Terfenadine (seldane®): A new drug for restoring sensitivity to multidrug resistant cancer cells

1993 • 53 citations

Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes.

1984 • 49 citations

Metabolic disposition of terfenadine in laboratory animals.

1982 • 47 citations

Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein.

2000 • 39 citations

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose.

1990 • 38 citations

APPLICATION OF COMPARTMENTAL MODELING TO AN EXAMINATION OF IN VITRO INTESTINAL PERMEABILITY DATA: ASSESSING THE IMPACT OF TISSUE UPTAKE, P-GLYCOPROTEIN, AND CYP3A

2003 • 34 citations

Temperature programming in macrocycle-based ion chromatography

1991 • 28 citations

Sequestered endoplasmic reticulum space for sequential metabolism of salicylamide. Coupling of hydroxylation and glucuronidation.

1996 • 24 citations

Evaluation of drug interactions in intact hepatocytes: Inhibitors of terfenadine metabolism

1996 • 20 citations

Induction of CYP3A and associated terfenadineN-dealkylation in rat hepatocytes cocultured with 3T3 cells

1995 • 11 citations

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Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic… (2006) – Journal of Pharmacology and Experimental Therapeutics | Metascience Observatory Explorer