Induction of CYP3A and associated terfenadineN-dealkylation in rat hepatocytes cocultured with 3T3 cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

1983 • 511 citations

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1988 • 470 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Evaluation of cytotoxicity in cultured cells by enzyme leakage

1980 • 228 citations

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

1993 • 225 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo.

1984 • 175 citations

GenBank

1994 • 174 citations

Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals.

1994 • 166 citations

The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system

1990 • 155 citations

Primary cultures of hepatocytes on human fibroblasts

1979 • 119 citations

Cultivation of adult rat hepatocytes on 3T3 cells: expression of various liver differentiated functions

1989 • 94 citations

Activities of several phase I and phase II xenobiotic biotransformation enzymes in cultured hepatocytes from male and female rats

1985 • 72 citations

Long-term culture of functional hepatocytes

1990 • 72 citations

Mouse liver cytochrome P-450 (P-450IIIAm1): its cDNA cloning and inducibility by dexamethasone

1992 • 70 citations

[33] Induction protocols for cytochromes P450IIIA in Vivo and in primary cultures of animal and human hepatocytes

1991 • 69 citations

Maintenance of adult rat hepatocytes on C3H/10T1/2 cells.

1979 • 60 citations

Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase

1993 • 55 citations

Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers

1994 • 43 citations

Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells

1991 • 39 citations

Rat adult hepatocytes in primary pure and mixed monolayer culture

1991 • 37 citations

Pregnenolone 16 Alpha-Carbonitrile-Inducible P-450 Gene Family: Gene Conversion and Differential Regulation

1986 • 35 citations

Catalytic and immunologic characterization of hepatic and lung cytochromes P450 in the polar bear

1995 • 34 citations

Mechanism of maintenance of liver-specific functions by DMSO in cultured rat hepatocytes

1991 • 33 citations

Effects of ethanol and clofibrate on expression of cytochrome P‐450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes

1991 • 25 citations

Enalapril cytotoxicity in primary cultures of rat hepatocytes. I. Effects of cytochrome P450 inducers and inhibitors

1991 • 21 citations

Maintenance of total cytochrome P-450 content in rat hepatocyte culture and the abundance of CYP1A2 and CYP2B1/2 mRNAs

1992 • 19 citations

Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines

1990 • 18 citations

Toxicology Studies in Cultured Hepatocytes from Various Species

1987 • 18 citations