EFFECT OF DEXAMETHASONE TREATMENT ON THE EXPRESSION AND FUNCTION OF TRANSPORT PROTEINS IN SANDWICH-CULTURED RAT HEPATOCYTES

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Bile Salt Transporters: Molecular Characterization, Function, and Regulation

2003 • 946 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

2001 • 753 citations

The Orphan Nuclear Receptor, shp, Mediates Bile Acid-Induced Inhibition of the Rat Bile Acid Transporter, ntcp

2001 • 434 citations

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver

2001 • 284 citations

Conditions affecting primary cell cultures of functional adult rat hepatocytes

1976 • 265 citations

Characterization of inducible nature of MRP3 in rat liver

2000 • 255 citations

Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition

2002 • 240 citations

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

1999 • 223 citations

In situ localization of the hepatocytic na+/taurocholate cotransporting polypeptide in rat liver

1994 • 221 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

Drug metabolism in hepatocyte sandwich cultures of rats and humans

1997 • 182 citations

Pharmacokinetics of 5 (and 6)-Carboxy-2′,7′-Dichlorofluorescein and Its Diacetate Promoiety in the Liver

2003 • 163 citations

Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver

2000 • 144 citations

Cultured Rat Hepatocytes

1996 • 136 citations

Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16α-carbonitrile Is via Interaction with Pregnane X Receptor

2002 • 124 citations

Trafficking of Canalicular ABC Transporters in Hepatocytes

2002 • 121 citations

Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes

2001 • 107 citations

Up‐regulation of multidrug resistance‐associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone

1999 • 101 citations

P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.

2001 • 93 citations

Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat

2002 • 89 citations

Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration.

1998 • 84 citations

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.

1992 • 84 citations

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

2002 • 83 citations

Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes

1996 • 75 citations

Two-Stage Glucocorticoid Induction ofCYP3A23through Both the Glucocorticoid and Pregnane X Receptors

2000 • 74 citations

Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase

1989 • 70 citations

Regulation of biliary drug efflux pump expression by hormones and xenobiotics

2001 • 64 citations

Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways

2002 • 60 citations

Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture

1992 • 58 citations

Regulation of Bile Salt Export Pump mRNA Levels by Dexamethasone and Osmolarity in Cultured Rat Hepatocytes

1999 • 55 citations

OPTIMIZATION OF CULTURE CONDITIONS FOR DETERMINING HEPATOBILIARY DISPOSITION OF TAUROCHOLATE IN SANDWICH-CULTURED RAT HEPATOCYTES

2001 • 47 citations

Role of Protein Phosphatases in Cyclic AMP-mediated Stimulation of Hepatic Na+/Taurocholate Cotransport

1998 • 43 citations

Differential modulation of P-glycoprotein expression by dexamethasone and 3-methycholanthrene in rat hepatocyte primary cultures

1994 • 42 citations

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes

2000 • 40 citations

The effects of dexamethasone on metabolic activity of hepatocytes in primary monolayer culture

1980 • 32 citations

Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations

2000 • 18 citations