The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Human cytochromes P450: problems and prospects

1992 • 364 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

1990 • 310 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

The UDP Glucuronosyltransferase Gene Super family: Suggested Nomenclature Based on Evolutionary Divergence

1991 • 275 citations

The role of individual human cytochrpmes P450 in drug metabolism and clinical response

1992 • 246 citations

Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease

1993 • 232 citations

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

1992 • 230 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development

1993 • 193 citations

Pharmacogenetic Phenotyping and Genotyping

1994 • 189 citations

Cytochrome P450 Enzymes

2010 • 172 citations

Clinical Pharmacokinetics in Patients with Liver Disease

1991 • 147 citations

The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression

1994 • 123 citations

Use of human hepatocyte cultures for drug metabolism studies

1993 • 119 citations

Characterization of cytochrome P-450 2B6 in human liver microsomes.

1993 • 107 citations

Ethnic differences in response to morphine

1993 • 98 citations

Cryopreservation of human adult hepatocytes for use in drug metabolism and toxicity studies

1993 • 62 citations

Gender‐Related Differences in Xenobiotic Metabolism

1991 • 60 citations

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

1992 • 49 citations

Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism

1992 • 43 citations

Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells

1993 • 40 citations

Genetically Determined Adverse Drug Reactions Involving Metabolism

1993 • 35 citations

Role of metabolism and pharmacokinetic studies in the discovery of new drugs—present and future perspectives

1992 • 30 citations

Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity

1993 • 25 citations

In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A.

1994 • 24 citations

Precision-Cut Rat Liver Slices in Dynamic Organ Culture for Structure-Toxicity Studies

1990 • 20 citations

Use of established hepatoma cell lines in biotoxicology

1993 • 5 citations

Disposition of zatosetron, a serotonin (5-HT3) receptor antagonist, in humans.

1993 • 4 citations