Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes.

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Lymphocyte life-span and memory

1994 • 405 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.

1995 • 266 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

Peripheral blood lymphocytes as target cells of retroviral vector- mediated gene transfer

1994 • 246 citations

Expression of the ERBB3 gene product in breast cancer

1992 • 237 citations

Cancer immunology: the search for specificity.

1982 • 226 citations

Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.

1994 • 198 citations

Lysis of Autologous Melanoma Cells by Tumor*Infiltrating Lymphocytes: Association With Clinical Response

1991 • 196 citations

Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor.

1992 • 188 citations

Immunotherapy and gene therapy of cancer.

1991 • 177 citations

Lymphocytes as cellular vehicles for gene therapy in mouse and man.

1991 • 138 citations

Structural Mutations of the T Cell Receptor ζ Chain and Its Role in T Cell Activation

1990 • 132 citations

Epidermal Growth Factor Receptor, but Not c-erbB-2, Activation Prevents Lactogenic Hormone Induction of the β-Casein Gene in Mouse Mammary Epithelial Cells

1990 • 129 citations

Monoclonal antibodies against the extracellular domain of the erbB-2 receptor function as partial ligand agonists.

1992 • 121 citations

Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active.

1990 • 105 citations

A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity.

1995 • 99 citations

Targeted inhibition of tumor‐cell growth by recombinant heregulin‐toxin fusion proteins

1995 • 49 citations

Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells

1991 • 33 citations

The invasin protein of Yersinia spp. provides co‐stimulatory activity to human T cells through interaction with β integrins

1993 • 32 citations

Identification of Binding Sites for Neutralizing Monoclonal Antibodies on the 14-kDa Fusion Protein of Orthopox Viruses

1994 • 31 citations

Immunotherapy with Sensitized Lymphocytes

1992 • 25 citations

Development of retrovirally marked human T progenitor cells into mature thymocytes

1995 • 20 citations

Heterogeneous lymphokine-activated killer cell precursor populations

1989 • 19 citations