Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections

Hay fever, hygiene, and household size.

1989 • 4,910 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

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Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Family size, infection and atopy: the first decade of the 'hygiene hypothesis'

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Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

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Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

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IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Give us this day our daily germs

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Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance.

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Mechanisms for the induction of autoimmunity by infectious agents

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Impairment of Tetanus Toxoid-Specific Thl-like Immune Responses in Humans Infected with Schistosoma mansoni

1996 • 328 citations

Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease

2001 • 326 citations

Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette–Guérin (BCG) vaccination

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Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice

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IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

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Does the failure to acquire helminthic parasites predispose to Crohn's disease?

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Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Human Infection withAscaris lumbricoidesIs Associated with a Polarized Cytokine Response

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Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

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The Epidemiology of Multiple Sclerosis

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Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

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IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

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Crossregulation Between Th1 and Th2 Cells

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Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.

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Changes in Cytokine Production after Measles Virus Vaccination: Predominant Production of IL-4 Suggests Induction of a Th2 Response

1993 • 167 citations

A Critical Role for IL-4 in Regulating Disease Severity in Experimental Allergic Encephalomyelitis as Demonstrated in IL-4-Deficient C57BL/6 Mice and BALB/c Mice

1998 • 161 citations

Immune dysregulation to Ethiopian immigrants in Israel: relevance to helminth infections?

1996 • 149 citations

Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses.

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Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis

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MS epidemiology world wide. One view of current status

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A T Helper Cell 2 (Th2) Immune Response against Non-self Antigens Modifies the Cytokine Profile of Autoimmune T Cells and Protects against Experimental Allergic Encephalomyelitis

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Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state.

2001 • 126 citations

Early social mixing and childhood Type 1 diabetes mellitus: a case–control study in Yorkshire, UK

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Immunopathogenesis of herpetic ocular disease

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The central nervous system environment controls effector CD4⁺ T cell cytokine profile in experimental allergic encephalomyelitis

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Autoimmunity and malaria: what are they doing together?

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Mycobacteria induce CD4⁺ T cells that are cytotoxic and display Th1‐like cytokine secretion profile: Heterogeneity in cytotoxic activity and cytokine secretion levels

1993 • 100 citations

Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis

1998 • 95 citations

Herpes Simplex Virus-Induced Keratitis: Evaluation of the Role of Molecular Mimicry in Lesion Pathogenesis

2001 • 83 citations

Anti-proliferative effect of IFN-gamma in immune regulation. II. IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor.

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Activation and Functions of CD4⁺ T‐Cell Subsets

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Human Immunity toSchistosoma Mansoni: Observations on Mechanisms, and Implications for Control

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Do common childhood infections ‘teach’ the immune system not to be allergic?

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Preferential induction of cell‐mediated immunity by chemically modified sheep erythrocytes

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Beneficial effect of polyclonal immunoglobulins from malaria‐infected BALB/c mice on the lupus‐like syndrome of (NZB × NZW)F1 mice

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Bacterial agents protect against autoimmune disease. I. Mice pre-exposed to Bordetella pertussis or Mycobacterium tuberculosis are highly refractory to induction of experimental autoimmune encephalomyelitis

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Epidemiology of Multiple Sclerosis

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Infections and risk of Type I (insulin-dependent) diabetes mellitus in Lithuanian children

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Why is the prevalence of allergy and autoimmunity increasing?

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PROLONGATION OF RAT KIDNEY ALLOGRAFT SURVIVAL BY NEMATODES1,2

1996 • 42 citations

Risk factors in multiple sclerosis: Tuberculin reactivity, age at measles infection, tonsillectomy and appendectomy

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Differential Influence of Interleukin-12 in the Pathogenesis of Autoimmune and Virus-Induced Central Nervous System Demyelination

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Mechanisms ofMycobacterium avium-induced resistance against insulin-dependent diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice: role of Fas and Th1 cells

1999 • 38 citations

A 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. Protection in the absence of shared T cell epitopes with encephalitogenic proteins.

1995 • 38 citations

Protection against autoimmune disease by bacterial agents. II. PPD and pertussis toxin as proteins active in protecting mice against experimental autoimmune encephalomyelitis

1993 • 37 citations

The Initiation and Function of Th2 Responses during Infection with Schistosoma Mansoni

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Parasite-mediated down-regulation of collagen-induced arthritis (CIA) in DA rats

2000 • 34 citations

Th1 and Th2 cells

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Cinderella goes to the ball

2001 • 29 citations

A role for CD45RB^low CD38⁺ T cells and costimulatory pathways of T‐cell activation in protection of non‐obese diabetic (NOD) mice from diabetes

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Is there a role for autoimmunity in immune protection against malaria?

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IBD: immunologic research at The Mount Sinai Hospital.

2000 • 8 citations

The fate of adoptively transferred quiescent encephalitogenic T cells in normal and antigen-tolerized mice

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Prevention of adjuvant arthritis in Lewis rats by neonatal bacille Calmette–Guérin (BCG) infection

1996 • 7 citations

Natural and experimental transfer of anti-Pertussis antibodies confers resistance to experimental autoimmune encephalomyelitis

1993 • 4 citations