The Initiation and Function of Th2 Responses during Infection with Schistosoma Mansoni

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

1995 • 493 citations

Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

1992 • 424 citations

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1995 • 403 citations

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni.

1993 • 337 citations

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

1994 • 276 citations

IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis.

1997 • 262 citations

Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.

1986 • 241 citations

Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages

1994 • 237 citations

Th2 Cells Are Required for theSchistosoma mansoniEgg-Induced Granulomatous Response

1998 • 227 citations

Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils.

1996 • 204 citations

Cytokines in Health and Disease

1992 • 199 citations

CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.

1992 • 171 citations

The Role of Nitric Oxide in Inflammation

1995 • 170 citations

Anti-L3T4 antibody treatment suppresses hepatic granuloma formation and abrogates antigen-induced interleukin-2 production in Schistosoma mansoni infection

1986 • 160 citations

[Cytokines in health and disease].

1996 • 155 citations

The 55-kD Tumor Necrosis Factor Receptor and CD95 Independently Signal Murine Hepatocyte Apoptosis and Subsequent Liver Failure

1996 • 130 citations

The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice.

1996 • 105 citations

Multiple Pathways for the Initiation of T Helper 2 (Th2) Responses

1997 • 103 citations

Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. I. Pathogenesis.

1979 • 102 citations

The purification, characterization, serological activity and hepatotoxic properties of two cationic glycoproteins (α₁and ω₁) fromSchistosoma mansonieggs

1991 • 99 citations

Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni

1997 • 98 citations

Mechanisms of immune evasion in schistosomiasis.

1987 • 87 citations

Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population.

1996 • 85 citations

Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population.

1997 • 78 citations

Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs.

1995 • 73 citations

In Vivo Microscopic Observations of the Pathogenesis and Pathophysiology of Hepatosplenic Schistosomiasis in the Mouse Liver

1972 • 52 citations

Physiology and Pathophysiology

2007 • 41 citations

T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice.

1996 • 28 citations

Role of NO and Nitrogen Intermediates in Regulation of Cell Functions

1997 • 8 citations

Tolerance against tumor necrosis factor α (TNF)-induced hepatotoxicity in mice: the role of nitric oxide

1995 • 7 citations