Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Interleukin-10

1993 • 1,820 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Cytokine patterns in the pathogenesis of human leishmaniasis.

1993 • 372 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

1993 • 317 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

1991 • 259 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

Immune regulation: a new role for the CD8+ T cell

1994 • 179 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection.

1989 • 138 citations

Heterogeneity in Lymphokine Profiles of CD4⁺ and CD8⁺ T Cells and Clones Activated in vivo and in vitro

1991 • 132 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

Comparison of diversity and function of house dust mite‐specific T lymphocyte clones from atopic and non‐atopic donors

1990 • 113 citations

Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis.

1992 • 104 citations

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo.

1993 • 98 citations

Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen.

1993 • 97 citations

T helper cells grown with hapten‐modified cultured Langerhans' cells produce interleukin 4 and stimulate IgE production by B cells

1989 • 82 citations

Allergen-specific modulation of cytokine synthesis patterns and IgE responses in vivo with chemically modified allergen.

1993 • 43 citations

Biological Role of Helper T-Cell Subsets in Helminth Infections

2015 • 30 citations

Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis.

1991 • 30 citations

Profound specific suppression by antigen of persistent IgM, IgG, and IgE antibody production.

1992 • 29 citations

Rapid establishment of a stable IL-4/IFN-γ production profile in the antigen-specific CD4⁺ T cell response to protein immunization

1994 • 21 citations

Antigen-specific modulation of murine IgE and IgG2a responses with glutaraldehyde-polymerized allergen is independent of MHC haplotype and Igh allotype.

1991 • 10 citations