Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Smallpox and its eradication

1988 • 1,387 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Nonreplicating vaccinia vector efficiently expresses recombinant genes.

1992 • 598 citations

Complications of Smallpox Vaccination, 1968

1969 • 545 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

NYVAC: A highly attenuated strain of vaccinia virus

1992 • 473 citations

Strategies for designing and optimizing new generation vaccines

2001 • 338 citations

[The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)].

1978 • 308 citations

Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara

1996 • 307 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Vaccinia Virus Envelope H3L Protein Binds to Cell Surface Heparan Sulfate and Is Important for Intracellular Mature Virion Morphogenesis and Virus Infection In Vitro and In Vivo

2000 • 283 citations

Nonparametric methods in factorial designs

2001 • 269 citations

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

1998 • 265 citations

Basic and applied influenza research

1982 • 255 citations

Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

2001 • 240 citations

A constitutively expressed vaccinia gene encodes a 42-kDa glycoprotein related to complement control factors that forms part of the extracellular virus envelope

1992 • 218 citations

Neutralizing and Protective Antibodies Directed against Vaccinia Virus Envelope Antigens

1999 • 205 citations

T Cell Response to Viral and Bacterial Infection

1974 • 197 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

DNA Vaccination with Vaccinia Virus L1R and A33R Genes Protects Mice against a Lethal Poxvirus Challenge

2000 • 182 citations

A Myristylated Membrane Protein Encoded by the Vaccinia Virus L1R Open Reading Frame Is the Target of Potent Neutralizing Monoclonal Antibodies

1995 • 180 citations

Dose-Related Effects of Smallpox Vaccine

2002 • 179 citations

Isolation and characterization of neutralizing monoclonal antibodies to vaccinia virus

1985 • 174 citations

Bioterrorism: A clear and present danger

2001 • 171 citations

Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity

1999 • 170 citations

The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.

1998 • 167 citations

Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection

1996 • 165 citations

Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication

1995 • 164 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines

2002 • 158 citations

Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.

1996 • 157 citations

Developing New Smallpox Vaccines

2001 • 139 citations

Role of Cellular Immunity in Protection against HIV Infection**This article was accepted for publication on 31 October 1996.

1997 • 127 citations

Biological characterization of recombinant vaccinia viruses in mice infected by the respiratory route

1990 • 115 citations

Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

1998 • 111 citations

The Use of Vaccinia Hyperimmune Gammaglobulin in the Prophylaxis of Smallpox

2015 • 111 citations

Importance of B cells, but Not Specific Antibodies, in Primary and Secondary Protective Immunity to the Intracellular BacteriumFrancisella tularensisLive Vaccine Strain

1999 • 106 citations

Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections

1999 • 97 citations

Th Cell-Deficient Mice Control Influenza Virus Infection More Effectively Than Th- and B Cell-Deficient Mice: Evidence for a Th-Independent Contribution by B Cells to Virus Clearance

2000 • 96 citations

Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy

2002 • 91 citations

Interplay of Cytokines and Adjuvants in the Regulation of Mucosal and Systemic HIV-Specific CTL

2000 • 86 citations

Vaccinia Virus Expression Vector: Coexpression of β-Galactosidase Provides Visual Screening of Recombinant Virus Plaques

1985 • 76 citations

Vaccination with DNA encoding internal proteins of influenza virus does not require CD8+ cytotoxic T lymphocytes: either CD4+ or CD8+ T cells can promote survival and recovery after challenge

2000 • 76 citations

SMALLPOX VACCINATION OF ECZEMA PATIENTS WITH A STRAIN OF ATTENUATED LIVE VACCINIA (CVI-78)

1968 • 57 citations

Modeling a Safer Smallpox Vaccination Regimen, for Human Immunodeficiency Virus Type 1–Infected Patients, in Immunocompromised Macaques

2003 • 44 citations

Novel vaccinia vector derived from the host range restricted and highly attenuated MVA strain of vaccinia virus.

1995 • 41 citations

Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines

1994 • 24 citations