Wild-Type Levels of Nuclear Localization and Human Immunodeficiency Virus Type 1 Replication in the Absence of the Central DNA Flap

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

2000 • 943 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap

2000 • 831 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

A quantitative assay for HIV DNA integration in vivo

2001 • 692 citations

Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding

2000 • 662 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

Human immunodeficiency virus infection of cells arrested in the cell cycle.

1992 • 523 citations

A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.

1994 • 491 citations

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

1995 • 428 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI

1991 • 388 citations

A nucleoprotein complex mediates the integration of retroviral DNA.

1989 • 381 citations

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

1994 • 381 citations

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.

1991 • 358 citations

A molecular clone of HTLV-III with biological activity

1985 • 320 citations

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication

1992 • 294 citations

Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1990 • 268 citations

Integration of human immunodeficiency virus type 1 DNA in vitro.

1990 • 257 citations

Use of Real-Time PCR and Molecular Beacons To Detect Virus Replication in Human Immunodeficiency Virus Type 1-Infected Individuals on Prolonged Effective Antiretroviral Therapy

1999 • 252 citations

Efficient HIV-1 replication can occur in the absence of the viral matrix protein

1998 • 236 citations

The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells

2000 • 217 citations

HIV-1 Infection Requires a Functional Integrase NLS

2001 • 201 citations

The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain

2001 • 200 citations

Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses.

1993 • 189 citations

Mutations altering the Moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle

1999 • 159 citations

A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract

1991 • 148 citations

Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import

2002 • 148 citations

Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase

2001 • 120 citations

Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways

2001 • 117 citations

Nuclear Import of Human Immunodeficiency Virus Type-1 Preintegration Complexes

1999 • 113 citations

Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines

2001 • 111 citations

A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration

1997 • 100 citations

Modified HIV-1 Based Lentiviral Vectors Have an Effect on Viral Transduction Efficiency and Gene Expression in Vitro and in Vivo

2001 • 99 citations

Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap

2001 • 97 citations

Multiple Integrase Functions Are Required to Form the Native Structure of the Human Immunodeficiency Virus Type I Intasome

1999 • 96 citations

Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease

1997 • 88 citations

Journey to the Center of the Cell

2001 • 87 citations

Structure-Based Mutagenesis of the Human Immunodeficiency Virus Type 1 DNA Attachment Site: Effects on Integration and cDNA Synthesis

1999 • 81 citations

The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells

2000 • 76 citations

Infection of Nondividing Cells by Rous Sarcoma Virus

2001 • 70 citations

Mutations in the central polypurine tract of HIV-1 result in delayed replication

1992 • 57 citations

Use ofcis- andtrans-Acting Viral Regulatory Sequences to Improve Expression of Human Immunodeficiency Virus Vectors in Human Lymphocytes

1996 • 55 citations

Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus

1998 • 50 citations

Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo

1997 • 48 citations

Asymmetric Processing of Human Immunodeficiency Virus Type 1 cDNA In Vivo: Implications for Functional End Coupling during the Chemical Steps of DNA Transposition

2001 • 44 citations

The plus strand is discontinuous in a subpopulation of unintegrated HIV-1 DNA

1991 • 43 citations

Rescue of Multiple Viral Functions by a Second-Site Suppressor of a Human Immunodeficiency Virus Type 1 Nucleocapsid Mutation

2000 • 30 citations