Multiple Integrase Functions Are Required to Form the Native Structure of the Human Immunodeficiency Virus Type I Intasome

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

1984 • 3,959 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Crystal Structure of the Catalytic Domain of HIV-1 Integrase: Similarity to Other Polynucleotidyl Transferases

1994 • 804 citations

Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition

1997 • 600 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Correct integration of retroviral DNA in vitro

1987 • 459 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

1995 • 428 citations

Retroviral DNA integration: Structure of an integration intermediate

1988 • 397 citations

A nucleoprotein complex mediates the integration of retroviral DNA.

1989 • 381 citations

Restricted expression of human T-Cell leukemia-lymphoma virus (HTLV) in Transformed human umbilical cord blood lymphocytes

1983 • 332 citations

Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

1998 • 271 citations

Integration of human immunodeficiency virus type 1 DNA in vitro.

1990 • 257 citations

Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.

1984 • 244 citations

The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding

1994 • 238 citations

Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.

1994 • 238 citations

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection

1996 • 232 citations

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

1997 • 229 citations

High-resolution Structure of the Catalytic Domain of Avian Sarcoma Virus Integrase

1995 • 228 citations

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex

1999 • 197 citations

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.

1993 • 197 citations

Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types

1991 • 191 citations

The barrier-to-autointegration protein is a host factor for HIV type 1 integration

1998 • 188 citations

Human immunodeficiency virus integration in a cell-free system

1990 • 182 citations

In Vivo Analysis of Retroviral Integrase Structure and Function

1999 • 169 citations

Transposition of Phage Mu DNA

1996 • 150 citations

Retroviral Integrase, Putting the Pieces Together

1996 • 135 citations

Mapping Features of HIV-1 Integrase Near Selected Sites on Viral and Target DNA Molecules in an Active Enzyme−DNA Complex by Photo-Cross-Linking

1997 • 134 citations

A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration

1997 • 100 citations

Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini

1996 • 86 citations

Effects of Mutations in Residues near the Active Site of Human Immunodeficiency Virus Type 1 Integrase on Specific Enzyme-Substrate Interactions

1998 • 84 citations

Concerted integration of retrovirus-like DNA by human immunodeficiency virus type 1 integrase

1995 • 83 citations

Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase

1997 • 73 citations

Efficient autointegration of avian retrovirus DNA in vitro

1990 • 58 citations

Footprints on the viral DNA ends in Moloney murine leukemia virus preintegration complexes reflect a specific association with integrase

1998 • 56 citations

Efficient concerted integration of retrovirus-like DNA in vitro by avian myeloblastosis virus integrase

1994 • 55 citations

Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitro

1996 • 43 citations