Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

1996 • 1,516 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap

2000 • 831 citations

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

1993 • 810 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

Specific incorporation of cyclophilin A into HIV-1 virions

1994 • 736 citations

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

1997 • 732 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition

1997 • 600 citations

Binding and Stimulation of HIV-1 Integrase by a Human Homolog of Yeast Transcription Factor SNF5

1994 • 523 citations

Human immunodeficiency virus infection of cells arrested in the cell cycle.

1992 • 523 citations

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1997 • 483 citations

Positional cloning of the mouse retrovirus restriction gene Fvl

1996 • 481 citations

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.

1993 • 449 citations

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1992 • 399 citations

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

1994 • 381 citations

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase

1995 • 360 citations

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.

1991 • 358 citations

HIV-1 cDNA Integration: Requirement of HMG I(Y) Protein for Function of Preintegration Complexes In Vitro

1997 • 358 citations

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

2001 • 351 citations

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import

1997 • 340 citations

HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

1998 • 332 citations

Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription

1996 • 327 citations

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex

1998 • 320 citations

Characterization of Intracellular Reverse Transcription Complexes of Human Immunodeficiency Virus Type 1

2001 • 311 citations

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1995 • 309 citations

Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex

1991 • 304 citations

Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection

1995 • 300 citations

Mechanisms of viral transport in the cytoplasm

2000 • 299 citations

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication

1992 • 294 citations

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

1994 • 287 citations

Establishment of a Functional Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcription Complex Involves the Cytoskeleton

1998 • 276 citations

Reverse Transcriptase and the Generation of Retroviral DNA

1997 • 271 citations

A previously unidentified host protein protects retroviral DNA from autointegration

1998 • 267 citations

Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex

2000 • 257 citations

A Role for DNA-PK in Retroviral DNA Integration

1999 • 255 citations

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import

1996 • 253 citations

A conserved mechanism of retrovirus restriction in mammals

2000 • 240 citations

Efficient HIV-1 replication can occur in the absence of the viral matrix protein

1998 • 236 citations

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

1996 • 235 citations

Foamy Viruses Are Unconventional Retroviruses

1999 • 233 citations

Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA

1977 • 220 citations

Viral Entry into the Nucleus

2000 • 220 citations

The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells

2000 • 217 citations

A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES

1971 • 215 citations

Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin

1986 • 212 citations

Transcriptionally active genome regions are preferred targets for retrovirus integration

1990 • 210 citations

HIV-1 Infection Requires a Functional Integrase NLS

2001 • 201 citations

Repair of Gaps in Retroviral DNA Integration Intermediates

2000 • 198 citations

The barrier-to-autointegration protein is a host factor for HIV type 1 integration

1998 • 188 citations

Characterization of HIV-1 Vpr Nuclear Import: Analysis of Signals and Pathways

1998 • 186 citations

Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex

1998 • 185 citations

Coupled Integration of Human Immunodeficiency Virus Type 1 cDNA Ends by Purified Integrase In Vitro: Stimulation by the Viral Nucleocapsid Protein

1999 • 177 citations

Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex

1998 • 175 citations

Mutations altering the Moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle

1999 • 159 citations

Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors

1994 • 154 citations

Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

1996 • 154 citations

Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells

1996 • 146 citations

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1985 • 145 citations

Isolation and Characterization of a Near-Haploid Human Cell Line

1999 • 142 citations

Viral transport and the cytoskeleton

2001 • 139 citations

Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex 1 1Edited by M. Gottesman

2000 • 138 citations

Characterization of Intracellular Reverse Transcription Complexes of Moloney Murine Leukemia Virus

1999 • 138 citations

Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity

1995 • 137 citations

Interaction of the Human Immunodeficiency Virus Type 1 Nucleocapsid with Actin

1999 • 134 citations

The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus Replication

1979 • 132 citations

Identification of Critical Amino Acid Residues in Human Immunodeficiency Virus Type 1 IN Required for Efficient Proviral DNA Formation at Steps prior to Integration in Dividing and Nondividing Cells

2000 • 130 citations

Characterization of HIV Replication Complexes Early after Cell-to-Cell Infection

1993 • 129 citations

Physical mapping of the Fv-1 tropism host range determinant of BALB/c murine leukemia viruses

1983 • 129 citations

Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration

1998 • 124 citations

Postentry Restriction to Human Immunodeficiency Virus-Based Vector Transduction in Human Monocytes

2001 • 119 citations

Synthesis of Long, Representative DNA Copies of the Murine RNA Tumor Virus Genome

1976 • 114 citations

Nuclear Import of Human Immunodeficiency Virus Type-1 Preintegration Complexes

1999 • 113 citations

HIV-1 Gag Protein Associates with F-actin Present in Microfilaments

1996 • 108 citations

Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step

1997 • 107 citations

Six-NB-tropic murine leukemia viruses derived from a B-tropic virus of BALB/c have altered p30

1977 • 102 citations

Actin Associates with the Nucleocapsid Domain of the Human Immunodeficiency Virus Gag Polyprotein

1999 • 101 citations

A Ty1 Integrase Nuclear Localization Signal Required for Retrotransposition

1998 • 100 citations

Cellular Motor Protein KIF-4 Associates with Retroviral Gag

1999 • 100 citations

Requirements for different components of the host cell cytoskeleton distinguish ecotropic murine leukemia virus entry via endocytosis from entry via surface fusion

1997 • 99 citations

Multiple Integrase Functions Are Required to Form the Native Structure of the Human Immunodeficiency Virus Type I Intasome

1999 • 96 citations

Cell cycle dependence of foamy retrovirus infection

1995 • 95 citations

Cellular Distribution and Karyophilic Properties of Matrix, Integrase, and Vpr Proteins from the Human and Simian Immunodeficiency Viruses

2000 • 92 citations

Heat-Shock Protein 70 Can Replace Viral Protein R of HIV-1 during Nuclear Import of the Viral Preintegration Complex

2000 • 88 citations

Journey to the Center of the Cell

2001 • 87 citations

Retroviral cDNA Integration: Stimulation by HMG I Family Proteins

2000 • 86 citations

A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES

1973 • 84 citations

Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro

1992 • 82 citations

The Karyophilic Properties of Human Immunodeficiency Virus Type 1 Integrase Are Not Required for Nuclear Import of Proviral DNA

2000 • 80 citations

Structural Basis of DNA Bridging by Barrier-to-Autointegration Factor

2000 • 79 citations

In vitro synthesis of infectious DNA of murine leukaemia virus

1977 • 78 citations

Activation of Membrane Fusion by Murine Leukemia Viruses Is Controlled in cis or in trans by Interactions between the Receptor-Binding Domain and a Conserved Disulfide Loop of the Carboxy Terminus of the Surface Glycoprotein

2001 • 78 citations

Phosphorylation of Residue 131 of HIV-1 Matrix Is Not Required for Macrophage Infection

1997 • 71 citations

Nuclear Localization of Human Immunodeficiency Virus Type 1 Integrase Expressed as a Fusion Protein with Green Fluorescent Protein

1999 • 71 citations

Infection of Nondividing Cells by Rous Sarcoma Virus

2001 • 70 citations

Increased length of DNA made by virions of murine leukemia virus at limiting magnesium ion concentration

1977 • 70 citations

Modeling the Late Steps in HIV-1 Retroviral Integrase-catalyzed DNA Integration

2000 • 69 citations

Infectious Entry by Amphotropic as well as Ecotropic Murine Leukemia Viruses Occurs through an Endocytic Pathway

2001 • 67 citations

The C-Terminal Proline-Rich Tail of Human Immunodeficiency Virus Type 2 Vpx Is Necessary for Nuclear Localization of the Viral Preintegration Complex in Nondividing Cells

2000 • 66 citations

The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells

1998 • 66 citations

Human immunodeficiency virus type 1 2-LTR circles reside in a nucleoprotein complex which is different from the preintegration complex

1993 • 64 citations

Identification of the Regions of Fv1 Necessary for Murine Leukemia Virus Restriction

2001 • 62 citations

Binding of Murine Leukemia Virus Gag Polyproteins to KIF4, a Microtubule-Based Motor Protein

1998 • 62 citations

Intracellular transport of the murine leukemia virus during acute infection of NIH 3T3 cells: Nuclear import of nucleocapsid protein and integrase

1995 • 60 citations

Relationship between Retroviral DNA Integration and Gene Expression

2000 • 60 citations

Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases

1997 • 59 citations

Arginine Residues in the C-terminus of HIV-1 Vpr Are Important for Nuclear Localization and Cell Cycle Arrest

1998 • 59 citations

Diminished Human Immunodeficiency Virus Type 1 Reverse Transcription and Nuclear Transport in Primary Macrophages Arrested in Early G ₁ Phase of the Cell Cycle

2000 • 59 citations

Nucleotide sequences of gag-pol regions that determine the Fv-1 host range property of BALB/c N-tropic and B-tropic murine leukemia viruses

1983 • 58 citations

Footprints on the viral DNA ends in Moloney murine leukemia virus preintegration complexes reflect a specific association with integrase

1998 • 56 citations

Functional Analysis of the Simian Immunodeficiency Virus Vpx Protein: Identification of Packaging Determinants and a Novel Nuclear Targeting Domain

2001 • 52 citations

Two Putative α-Helical Domains of Human Immunodeficiency Virus Type 1 Vpr Mediate Nuclear Localization by at Least Two Mechanisms

2000 • 50 citations

Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal

1994 • 47 citations

Viral DNA Synthesis Defects in Assembly-Competent Rous Sarcoma Virus CA Mutants

2001 • 46 citations

Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core.

2000 • 46 citations

Phenotype of HIV-1 Lacking a Functional Nuclear Localization Signal in Matrix Protein ofgagand Vpr Is Comparable to Wild-Type HIV-1 in Primary Macrophages

1999 • 44 citations

A peptide derived from the N‐terminal region of HIV‐1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr

1998 • 42 citations

Somatic Cell Mutants Resistant to Retrovirus Replication: Intracellular Blocks during the Early Stages of Infection

1999 • 39 citations

Characterization of the nuclear localization signal in the avian sarcoma virus integrase1Published in conjunction with A Wisconsin Gathering Honoring Waclaw Szybalski on the occasion of his 75th year and 20years of Editorship-in-Chief of Gene, 10–11 August 1997, University of Wisconsin, Madison, WI, USA.1

1998 • 38 citations

Tagging the Human Immunodeficiency Virus Gag Protein with Green Fluorescent Protein

1999 • 35 citations

HIV-1 Nuclear Import: Matrix Protein Is Back on Center Stage, This Time Together with Vpr

1998 • 32 citations

Functional exchange of an oncoretrovirus and a lentivirus matrix protein

1994 • 31 citations

Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells

2000 • 31 citations

HIV nuclear import: What's the flap?

2000 • 30 citations

Evidence for Direct Association of Vpr and Matrix Protein p17 within the HIV-1 Virion

1996 • 26 citations

Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements

1997 • 25 citations

Natural endogenous reverse transcription of HIV-1

1998 • 24 citations

p17 and p17-ContaininggagPrecursors of Input Human Immunodeficiency Virus Are Transported into the Nuclei of Infected Cells

1991 • 23 citations

Host Proteins in Retroviral DNA Integration

1999 • 20 citations

Probing HIV's Elusive Activities Within the Host Cell

2000 • 8 citations

Intracellular Type A Retrovirus Movement Associated with an Intact Microtubule System

1985 • 8 citations